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Researchers have demonstrated that binge use of MDMA (ecstasy) can significantly alter cardiovascular function, including inducing cardiac arrhythmia and myocarditis, inflammation of the heart wall. In rats injected with MDMA, the risk of cardiac arrhythmia increased and the pattern of mean arterial pressure (MAP) and fluctuations in heart rate changed after repeated MDMA binges.
The quest for a fashion model's figure leads many girls and women to a cycle of weight loss and weight gain called yo-yo dieting. Some women never succeed in achieving or maintaining their desired weight, although some do. Researchers at the VA/Ann Arbor Healthcare System and the University of Michigan Health System are cautioning all women who yo-yo diet. Those who gain and/or lose at least 10 pounds in a yearlong period at least five times over a lifetime may be setting themselves up for heart problems after menopause.