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Tag: chronic myelogenous leukemia

International clinical trial tests targeted drug for melanoma

CHICAGO -- Rush University Medical Center has just enrolled the first U.S. patient in an international clinical trial testing a novel drug to treat certain kinds of melanoma, a deadly skin cancer that in its advanced stages currently has few effect...

Rare blood disease shown to be a form of treatable cancer

In the process of figuring out why an anti-cancer drug is effective in treating patients with a rare blood disorder known as hypereosinophilic syndrome, or HES, researchers at Brigham and Women's Hospital (BWH) and the Dana-Farber Cancer Institute have shown that the condition may in fact be a form of cancer.

Mechanism to overcome Gleevec resistance demonstrated

Amid the glowing results for chronic myelogenous leukemia (CML) patients using Gleevec the past three years, the one reality check has been that a majority of the patients with advanced disease eventually relapse and die of the leukemia. An article to be published in the Dec. 15 issue of the journal Cancer Research shows that, in the lab, the molecular mutations that produce a resistance to Gleevec can be overcome. Brian Druker, M.D., Howard Hughes Medical Institute Investigator and JELD-WEN Chair of Leukemia Research at the Oregon Health & Science University Cancer Institute, and colleagues report that a compound called PD180970 successfully stopped the activity of several mutations found in patients who developed a resistance to Gleevec.

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