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Shear force of blood flow is crucial to embryonic heart development

A team of California researchers has imaged the blood flow inside the heart of a growing embryonic zebrafish. The results demonstrate for the first time that the very action of high-velocity blood flowing over cardiac tissue is an important factor in the proper development of the heart–a result that could have profound implications for future surgical techniques and even for genetic engineering.

Medications underused in treating heart disease

Past studies have shown that various medications including beta blockers and aspirin can help manage heart disease. Yet a new study from Stanford University Medical Center indicates physicians continue to underprescribe these key treatments. The study appears in the Jan. 1 issue of the Journal of the American College of Cardiology. It focuses on the outpatient use of the drug warfarin for atrial fibrillation (or irregular heartbeat), beta blockers and aspirin for coronary artery disease, and ACE inhibitors for congestive heart failure – all medications that have been shown to benefit patients in past clinical trials and population studies.

Combination Pacemaker-Defibrillator Prevents Death from Heart Failure

A new implantable device has been found to reduce the risk of death from congestive heart failure by 40 percent, triggering the early halt of a national trial of the device. “This trial was the largest one in history to test an implanted pacemaker or defibrillator, and it represents a landmark study for the treatment of congestive heart failure,” says Mitchell N. Faddis, M.D., Ph.D., assistant professor of medicine at Washington University School of Medicine in St. Louis. “I think this is one of the most important therapies developed in the last decade for treatment of severe heart disease.”

Lifetime risk for heart failure: One in five

A person age 40 or older has a one-in-five chance of developing congestive heart failure, according to a study in today’s rapid access issue of Circulation: Journal of the American Heart Association. The study authors also reported that lifetime risk of developing heart failure doubles for people who have high blood pressure.

Rigorous, short-term diet-exercise program lowers heart disease risk

Obese men can significantly reduce heart disease risk on a three-week low-fat, high-fiber diet and daily exercise ? even though they may lose only a few pounds, according to research announced today in Circulation: Journal of the American Heart Association. Men who consumed a diet high in grains, vegetables and fruit and took brisk daily walks reduced their high blood pressure, a hallmark risk factor for congestive heart failure, kidney disease, coronary artery disease and stroke.