New clue to lupus: Failed autoimmune suppression mechanism

Bar Harbor, Maine — Researchers at Dana-Farber Cancer Institute in Cambridge, Mass., in collaboration with Jackson Laboratory scientists, have identified a regulatory defect that drives lupus.
Correcting the defect “may represent an effective t…

New test discovered to better predict breast cancer outcomes

Researchers from McGill University’s Rosalind and Morris Goodman Cancer Research Centre (GCRC), the Research Institute of the McGill University Health Centre (RI MUHC), the Dana — Farber Cancer Institute and Harvard Medical School have discovered a…

New studies examine links between XMRV and human disease

Xenotropic murine leukemia virus — related virus (XMRV) has been the subject of many studies since its discovery in 2006, but conflicting reports have created an unclear picture of XMRV’s role in human disease. In three recent studies published in …

Multivitamin use doesn’t impact colon cancer outcomes

BOSTON–Patients with colon cancer who used multivitamins during and after being treated with post-surgical chemotherapy did not reduce the risk of the cancer returning or their dying from it, according to researchers at Dana-Farber Cancer Ins…

Radiofrequency ablation effective in treating advanced lung cancer

Radiofrequency ablation can ease pain, slow tumor growth, and even destroy tumors in patients with advanced lung cancer, a new study shows. ?We treated 12 patients with thoracic tumors using radiofreqency ablation, which is the use of extreme heat to treat tumors,? says Eric vanSonnenberg, MD, chief of radiology at the Dana Farber Cancer Institute and visiting professor at Harvard Medical School in Boston, and lead author of the study. The patients either had maximal applications of surgery, chemotherapy, and radiation therapy or were unfit for these therapies anymore, Dr. vanSonnenberg says.

Male gene sparks immune reaction to stem cell transplants from female donors

Researchers report that in some cases of stem cell transplants from female donors to male recipients, the transplanted cells mount an immunological attack against the product of a gene carried by most cells in the body of male recipients. Emmanuel Zorn, PhD, says it is the first time that the gene, located on the Y chromosome and known as DBY, has been identified following a female-to-male stem cell transplant for leukemia.

Study sheds new light on how common painkillers prevent colon cancer

Building on earlier studies that have shown that common painkillers known as NSAIDs (non-steroidal anti-inflammatory drugs) can reduce the risk of colon cancer in healthy people, researchers at Dana-Farber Cancer Institute have identified a mechanism by which NSAIDs inhibit the development of colon cancer. Compared with normal cells, colorectal cancer cells have abnormally high levels of an immune system protein, IL-6. David Frank, MD, PhD, and his Dana-Farber colleagues have discovered that IL-6 triggers malignant growth by activating a protein called STAT1, which transmits signals that prevent the normal scheduled death of cells in the colon.

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