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New clue to lupus: Failed autoimmune suppression mechanism

Bar Harbor, Maine -- Researchers at Dana-Farber Cancer Institute in Cambridge, Mass., in collaboration with Jackson Laboratory scientists, have identified a regulatory defect that drives lupus. Correcting the defect "may represent an effective t...

New test discovered to better predict breast cancer outcomes

Researchers from McGill University's Rosalind and Morris Goodman Cancer Research Centre (GCRC), the Research Institute of the McGill University Health Centre (RI MUHC), the Dana -- Farber Cancer Institute and Harvard Medical School have discovered a...

New studies examine links between XMRV and human disease

Xenotropic murine leukemia virus -- related virus (XMRV) has been the subject of many studies since its discovery in 2006, but conflicting reports have created an unclear picture of XMRV's role in human disease. In three recent studies published in ...

Insurance and socioeconomic status do not explain racial disparities in breast...

Racial disparities in the receipt of breast cancer care persist despite accounting for patients' insurance and social and economic status. That is the conclusion of a study published early online in Cancer, a peer-reviewed journal of the American Ca...

Investigational ovarian cancer drug shows promise against platinum resistant disease

A drug being developed as a treatment for ovarian cancer has shown single agent activity with durable disease control in some patients in a Phase-II clinical trial, an international research group has reported. Dr Ursula Matulonis from Dana-Farber...

Multivitamin use doesn’t impact colon cancer outcomes

BOSTON--Patients with colon cancer who used multivitamins during and after being treated with post-surgical chemotherapy did not reduce the risk of the cancer returning or their dying from it, according to researchers at Dana-Farber Cancer Ins...

Sensitivity, resistance of tumor cells to chemo linked to genetic abnormality

Researchers at Dana-Farber Cancer Institute and a team of international collaborators have identified a genetic abnormality that makes ovarian tumor cells initially sensitive to a common chemotherapy agent, cisplatin, and then resistant to the drug over time.

Scientists report discovery of cancer-causing gene in childhood kidney tumor

In a discovery sparked by a routine check-up of a young cancer survivor, researchers at Dana-Farber Cancer Institute and Children's Hospital Boston have identified a gene responsible for a childhood form of the kidney tumor papillary renal cell carcinoma (PRCC).

Radiofrequency ablation effective in treating advanced lung cancer

Radiofrequency ablation can ease pain, slow tumor growth, and even destroy tumors in patients with advanced lung cancer, a new study shows. ?We treated 12 patients with thoracic tumors using radiofreqency ablation, which is the use of extreme heat to treat tumors,? says Eric vanSonnenberg, MD, chief of radiology at the Dana Farber Cancer Institute and visiting professor at Harvard Medical School in Boston, and lead author of the study. The patients either had maximal applications of surgery, chemotherapy, and radiation therapy or were unfit for these therapies anymore, Dr. vanSonnenberg says.

Male gene sparks immune reaction to stem cell transplants from female...

Researchers report that in some cases of stem cell transplants from female donors to male recipients, the transplanted cells mount an immunological attack against the product of a gene carried by most cells in the body of male recipients. Emmanuel Zorn, PhD, says it is the first time that the gene, located on the Y chromosome and known as DBY, has been identified following a female-to-male stem cell transplant for leukemia.

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