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Genetic sequencing alone doesn’t offer a true picture of human disease

DURHAM, N.C. -- Despite what you might have heard, genetic sequencing alone is not enough to understand human disease. Researchers at Duke University Medical Center have shown that functional tests are absolutely necessary to understand the biologi...

Findings on pollution damage to human airways could yield new therapies

DURHAM, N.C. -- Researchers from Duke University Medical Center have identified how nanoparticles from diesel exhaust damage lung airway cells, a finding that could lead to new therapies for people susceptible to airway disease. The scientists a...

Ovarian cancer screening saves few lives

The best currently available screening tests can only slightly reduce ovarian cancer deaths. That is the conclusion of new research published early online in Cancer, a peer-reviewed journal of the American Cancer Society. The results suggest that st...

Why so many antibodies fail to protect against HIV infection

DURHAM, NC -- Researchers have been stymied for years over the fact that people infected with the AIDS virus do indeed produce antibodies in response to the pathogen -- antibodies that turn out to be ineffective in blocking infection. Now, sci...

Tiny molecules protect from the dangers of sex

DURHAM, N.C. -- Pathogenic fungi have been found to protect themselves against unwanted genetic mutations during sexual reproduction, according to researchers at Duke University Medical Center. A gene-silencing pathway protects the fungal genome fr...

Statins don’t prove useful for general pediatric lupus population

ATLANTA, GA -- Lupus puts children at higher risk for coronary artery disease when they become adults, but routinely using statins doesn't provide enough benefit to warrant their regular use in children and adolescents, according to the largest st...

When docs counsel weight loss, it’s style that makes a difference

DURHAM, N.C. -- Most doctors are spending a good deal of time counseling their patients about diet and weight loss, but for the most part, it isn't making any difference, according to a new study appearing in the American Journal of Preventive Medi...

2 studies find new genetic links to ovarian cancer risk

DURHAM, N.C. -- An international consortium of scientists has discovered new genetic variants in five regions of the genome that affect the risk of ovarian cancer in the general population, according to two separate studies published today (Sunday)...

Engineered Proteins Will Lead to ‘Synthetic Biology’

Biochemists have developed a computational method to design proteins that can specifically detect a wide array of chemicals from TNT to brain chemicals involved in neurological disorders. In a paper in the May 8, 2003, issue of the journal Nature, they demonstrate the breadth of their design method, and also that such sensor proteins can be re-incorporated into cells to activate cellular signaling and genetic pathways.

Diet, Exercise Together Effective in Controlling High Blood Pressure

New research suggests that an overhaul of dietary and fitness habits to help prevent or control high blood pressure is feasible with proper coaching, contrary to the theory that too many changes would be overwhelming and ineffective for most people. The best results in the study were achieved when weight loss, salt restriction and exercise were paired with the DASH (Dietary Approaches to Stop Hypertension) diet, which is rich in fruits, vegetables and low fat dairy products.

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