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high density lipoprotein

Japanese kids gaining body fat, heart risks like Western counterparts

Japanese children are getting fatter – thus increasing their heart disease risk, researchers report today at the American Heart Association’s Second Annual Asia-Pacific Forum. Researchers at the Centers for Disease Control and Prevention (CDC) in Atlanta showed that an increase in body fat is linked to a rise in cholesterol levels – which is occurring in both U.S. and Japanese children. Historically, children in Japan have been leaner than their Western counterparts.

An enzyme puts the ‘good’ in good cholesterol

An oxidation-fighting enzyme called paraoxonase (PON1) can significantly reduce the risk of heart attacks, according to research reported in today’s rapid access issue of Circulation: Journal of the American Heart Association. The enzyme attaches itself to high-density lipoprotein (HDL), which is known as “good” cholesterol. When PON1 is highly active, the risk for heart attack is cut by 43 percent, says study author Michael Mackness, Ph.D., of the University Department of Medicine, Manchester Royal Infirmary, Manchester, United Kingdom.

How you respond to high-fat diet is linked to genes

Maybe people who eat fatty foods without negative health consequences really haven’t sold their souls to the devil. They may just have good genes. The link between dietary fat intake and heart disease is hardwired into our genes, according to research reported today. “This genetic mutation helps explain why some people are able to adapt to a Western high-fat diet, while others are not able to,” says lead author Jose M. Ordovas. The fat risk is greatest for people who have a specific genetic mutation in the hepatic lipase (LIPC) gene that is involved in the way high-density lipoprotein (HDL) ? “good cholesterol” ? is metabolized. The mutation is called ?514 (C/T) LIPC, and occurs in the promoter (or expression) region of the LIPC gene encoding the ?514 T allele.