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Quest for designer bacteria uncovers a ‘Spy’

ANN ARBOR, Mich.---Scientists have discovered a molecular assistant called Spy that helps bacteria excel at producing proteins for medical and industrial purposes. Bacteria are widely used to manufacture proteins used in medicine and indus...

Unlocking the secret(ase) of building neural circuits

LA JOLLA, CA -- Mutant presenilin is infamous for its role in the most aggressive form of Alzheimer's disease -- early-onset familial Alzheimer's -- which can strike people as early as their 30s. In their latest study, researchers at the Sal...

Missing molecules hold promise of therapy for pancreatic cancer

By determining what goes missing in human cells when the gene that is most commonly mutated in pancreatic cancer gets turned on, Johns Hopkins scientists have discovered a potential strategy for therapy. The production of a particular cluster of ...

Cholera and vaccine experts urge United States to stockpile vaccine

As the cholera epidemic in Haiti continues to rage, public health workers are focusing their efforts on treating the tens of thousands who have already been hospitalized with cholera-like symptoms and providing clean water and adequate sanitation to...

MIT biologists find that restoring the gene for cancer protein p53...

CAMBRIDGE, Mass. -- In a new study to be published in the Nov. 25 issue of Nature, MIT cancer biologists show that restoring the protein p53's function in mice with lung cancer has no effect early in tumor development, but restoring the function lat...

More evidence that melanoma does not conform to the cancer stem...

ANN ARBOR, Mich---University of Michigan researchers have determined that most types of melanoma cells can form malignant tumors, providing new evidence that the deadliest form of skin cancer does not conform to the increasingly popular cancer st...

Caltech scientists describe the delicate balance in the brain that controls...

PASADENA, Calif. -- The eerie music in the movie theater swells; the roller coaster crests and begins its descent; something goes bump in the night. Suddenly, you're scared: your heart thumps, your stomach clenches, your throat tightens, your muscle...

The zebrafish’s neural circuit prevents it from biting off more than...

Between alerting us to danger and allowing us to spot prey, vision keeps many animals, including humans, alive. But exactly how does this important sense work, and why is it easier for us to spot movement of small objects in our field of vision,...

Penn study identifies molecular guardian of cell’s RNA

PHILADELPHIA - When most genes are transcribed, the nascent RNAs they produce are not quite ready to be translated into proteins - they have to be processed first. One of those processes is called splicing, a mechanism by which non-coding gene...

‘Reaper’ protein strikes at mitochondria to kill cells

Our cells live ever on the verge of suicide, requiring the close attention of a team of molecules to prevent the cells from pulling the trigger. This self-destructive tendency can be a very good thing, as when dangerous precancerous cells are permit...

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