Lund adopts chromosome 19

The genes that make up the human genome were mapped by HUGO, the Human Genome Organisation, and published in 2001. Now the project is expanding into the HUPO, the Human Proteome Organisation. Within the framework of this organisation, many hundreds …

Tailor-made proteins manufactured in novel E. coli system

The prospect of using bacteria to manufacture complex human proteins for use in therapeutic drugs is a step closer thanks to new research published today in Science. Researchers from Switzerland and the UK report they have engineered the bacterium Escherichia coli to carry a vital piece of cell machinery that adds sugar molecules to newly synthesized proteins by a process known as glycosylation. The finding opens up the possibility of producing complex human proteins such as Factor VIII and the hormone erythropoietin, which stimulates the production of red blood cells by stem cells in bone marrow. Both these proteins, which require the addition of sugar molecules to function properly, are currently produced by culturing mammalian cells, which can be a costly and technically difficult process.

Dell embraces clusters

No one will begrudge Dell Computer its success in the marketing and sales realms. When it comes to getting companies and consumers to buy PCs, Dell sets the standard. But for such an accomplished firm, Dell has lacked the reputation for innovation and design smarts that companies like Apple, Hewlett-Packard and IBM have built. Apparently aware of that, wanting to make a change and still looking for the shortest possible path to a buck, Dell announced it will set up the Dell Centers for Research Excellence, a program that CNET’s News.com reports will acknowledge breakthroughs in PC clustering and take part in research with chosen universities. Clustering, for the uninitiated, is the process of linking several, sometimes hundreds of off-the-shelf PCs into one big computing leviathan. To kick off its effort, Dell unveiled Tuesday with the State University of New York at Buffalo a cluster of 2,008 Dell PowerEdge servers running Red Hat Linux. SUNY Buffalo researchers will use the cluster to study the structure and orientation of human proteins, CNET says, an important step in finding cures for many diseases. The Buffalo cluster is one of the largest of its kind, and in terms of sheer computing power makes the set-up one of the 500 fastest computers in the world.