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Cancer-causing virus exploits key cell-survival proteins

COLUMBUS, Ohio -- A cancer-causing retrovirus exploits key proteins in its host cells to extend the life of those cells, thereby prolonging its own survival and ability to spread, according to a new study by researchers at The Ohio State University...

Molecular network influences development of chronic lymphocytic leukemia

COLUMBUS, Ohio -- A study shows for the first time that the three most common chromosome changes seen in chronic lymphocytic leukemia disrupt a molecular network that includes several important genes and strongly influences the outcome of the disea...

Study provides molecular rationale for combining targeted agents to treat breast...

COLUMBUS, Ohio -- A new study by Ohio State University cancer researchers provides a rational for treating breast cancer by combining two kinds of targeted agents, one that inhibits an overactive, cancer-causing pathway in cancer cells and one that...

Virus might fight brain tumors better if armed with bacterial enzyme,...

COLUMBUS, Ohio -- New research shows that oncolytic viruses, which are engineered to destroy cancer cells, might be more effective in treating deadly brain tumors if equipped with an enzyme that helps them penetrate the tumor. The enzyme, called ...

Loss of gene promotes brain-tumor development, reduces survival, study finds

COLUMBUS, Ohio -- New research shows that loss of a gene called NFKBIA promotes the growth of glioblastoma multiforme, the most common and deadly form of brain cancer, and suggests that therapies that stabilize this gene may improve survival for c...

Tumor cells in blood may signal worse prognosis in head and...

COLUMBUS, Ohio -- A new study suggests that the presence of tumor cells in the circulating blood of patients with squamous cell cancer of the head and neck may predict disease recurrence and reduced survival. An increased number of circulating tumo...

Our normal genetics may influence cancer growth, too

COLUMBUS, Ohio -- The genes we possess not only determine the color of our eyes and hair and how our bodies grow, they might also influence the changes that occur in tumors when we develop cancer. A study by researchers at the Ohio State Universi...

Targeted agent shows promise for chronic lymphoid leukemia

COLUMBUS, Ohio -- Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) have identified an experimental agent that targets chronic lymphocytic l...

New model may simplify high-dose radiosurgery planning

COLUMBUS, Ohio -- There is yet no straightforward way to determine the optimal dose level and treatment schedules for high-dose radiation therapies such as stereotactic radiation therapy, used to treat brain and lung cancer, or for high-dose brachy...

Death, miscarriage linked to genetic mutation

Scientists have discovered that the genetic mutation that causes the childhood cancer retinoblastoma routinely triggers fetal death and miscarriage in laboratory animals by disrupting the normal functions of the placenta, a finding that may force researchers to reevaluate the powerful Rb gene and the role it plays in causing cancer.

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