A diagnostic marker in hepatocellular carcinoma

E2F5 is a member of the E2F transcription factor family, and plays a key role in cell growth and proliferation. Overexpression of E2F5 has been reported in various human cancers, but not in liver cancer, and its biological implication is largely unk…

Scientists find adult stem cells can heal diseased liver tissue

Researchers have explained how adult stem cells can heal diseased liver tissue. The research helps direct scientists in the quest for therapeutic uses of adult stem cells, which are derived from bone marrow. The research may also help define the therapeutic limits of these stem cells.

Discovery May Dramatically Reduce Liver Transplants in Children

A discovery published in the current issue of The Lancet may lead to new treatments for a deadly liver disease of infancy — dramatically reducing the number of liver transplants in children. A team of researchers at Cincinnati Children’s Hospital have revealed a genetic underpinning to biliary atresia, the most common reason for liver transplant in children. Biliary atresia occurs in infants and usually becomes evident two to eight weeks after birth. Its cause has been unknown. Symptoms include unexplained jaundice, dark urine, clay-colored stools and weight loss. The disease destroys bile ducts in the liver, trapping bile, rapidly causing damage to liver cells and severe scarring.

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