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Researchers discover genetic pathway in lupus

Researchers have identified a genetic “signature,” a series of genes that are activated by interferon in patients with severe systemic lupus erythematosus (SLE). This is the first time a signature pattern of gene expression has been identified in an autoimmune disease. The identification of this genetic signature may be used in the future to help diagnose lupus, predict the development of serious disease, and perhaps most importantly in treatment decisions.