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Swedish discovery could lead to new stroke therapy

The only acute treatment for a stroke currently available is thrombolysis. This uses drugs that dissolve the blood clot responsible for the stroke, but it only reaches around 10 per cent of stroke patients in time to prevent lasting damage. For other...

Nuclear receptors reveal possible interventions for cancer, obesity

HOUSTON, Jan. 10, 2011 -- Research with significant implications in the treatment and intervention of cancer and obesity has been published recently in two prestigious journals by University of Houston (UH) biochemist Dr. Jan-Åke Gustafsson....

Some cancer drugs may block cellular ‘cross talk’ but not kill...

AURORA, Colo. (Dec. 22, 2010) -- A class of drugs thought to kill cancer cells may in fact block "cross talk" between the cancer cell and normal immune cells, resulting in reduced cancer growth and spread -- a discovery that could significantly alte...

Carnegie Mellon researchers discover mechanism for signaling receptor recycling

PITTSBURGH -- An international team of researchers led by Carnegie Mellon University's Manojkumar Puthenveedu has discovered the mechanism by which signaling receptors recycle, a critical piece in understanding signaling receptor function. Wri...

How cells export and embed proteins in the membrane

Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-...

Drug-like compound stops thyroid overstimulation in early NIH studies

Researchers at the National Institutes of Health have identified a compound that prevents overproduction of thyroid hormone, a finding that brings scientists one step closer to improving treatment for Graves' disease. In Graves' disease, the thy...

Scripps Research scientists identify first synthetic activator of 2 critical proteins

JUPITER, FL, November 19, 2010 -- Scientists from the Florida campus of The Scripps Research Institute have identified a novel synthetic activator of a pair of proteins that belong to a protein family playing key roles in human metabolism and immun...

Scientists learn more about how kidneys fail and how new drugs...

Scientists are learning more about how protein gets in the urine when the kidneys begin to fail and how a new drug blocks it. "We have known for a long time that renal failure comes with protein in your urine, especially in diabetes," said...

Circuit regulating anti-diabetic actions of serotonin uncovered by UT Southwestern researchers

DALLAS -- Nov. 11, 2010 -- New findings by researchers at UT Southwestern Medical Center suggest that serotonin -- a brain chemical known to help regulate emotion, mood and sleep -- might also have anti-diabetic properties. The findings, app...

Scripps Research study challenges conventional theory of modern drug design

JUPITER, Fl, October 7, 2010 -- Scientists from The Scripps Research Institute have uncovered new evidence that challenges the current theory about a process key to the way modern drugs are designed and how they work in the human body. The new st...

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