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Researchers achieve germline transmission of ‘gene knockdown’ in mice

RNA interference (RNAi) has emerged as an extremely versatile and powerful tool in biomedical research. A new study published in the February issue of Nature Structural Biology reports the creation of transgenic mice in which inherited RNAi lowers or silences the expression of a target gene, producing a stable “gene knockdown.” This finding extends the power of RNAi to genetic studies in live animals, and has far-reaching implications for the study and treatment of many human diseases.