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Alzheimer's protein jams mitochondria; resulting 'energy crisis' kills neurons

Opening a new front in the battle against Alzheimer’s disease, scientists at the University of Pennsylvania have found that a protein long associated with the disease inflicts grave damage in a previously unimagined way: It seals off mitochondria in affected neurons, resulting in an “energy crisis” and buildup of toxins that causes cells to die. This pathway, the first specific biochemical explanation for pathologies associated with Alzheimer’s, is detailed in the April 14 issue of the Journal of Cell Biology.

Annual dog vaccines may not be necessary

Once a year, Ronald Schultz checks the antibody levels in his dogs’ blood. Why? He says for proof that most annual vaccines are unnecessary. Schultz, professor and chair of pathobiological sciences at the University of Wisconsin-Madison School of Veterinary Medicine, has been studying the effectiveness of canine vaccines since the 1970s; he’s learned that immunity can last as long as a dog’s lifetime, which suggests that our “best friends” are being over-vaccinated. Based on his findings, a community of canine vaccine experts has developed new veterinary recommendations that could eliminate a dog’s need for annual shots. The guidelines appear in the March/April issue of Trends, the journal of the American Animal Hospital Association (AAHA).

Tapeworm trick could make drugs more effective

To survive and thrive in a decidedly hostile environment, the lowly tapeworm uses a chemical trick to evade the propulsive nature of its intestinal home. Capitalizing on that tapeworm chemistry, scientists at the University of Wisconsin-Madison believe they may have found a way to slow the transit of drugs through the intestine, making them more effective in their delivery and holding out the promise not only of more effective treatment, but also of lowering dosage and cost, and eliminating wasted medicine.

Scientists solve puzzle of how influenza builds its infectious seeds

By solving a long-standing puzzle about how the influenza virus assembles its genetic contents into infectious particles that enable the virus to spread from cell to cell, scientists have opened a new gateway to a better understanding of one of the world’s most virulent diseases. This insight into the genetic workings that underpin infection by flu, reported in the Proceedings of the National Academy of Sciences, provides not only a better basic understanding of how flu and other viruses work, but holds significant promise for new and improved vaccines and drugs to combat the disease by exposing the genetic trick it uses to form virus particles.

Dogs on fatty diet may give clues to human disease development

Coonhound puppies on diets containing the type of fat found in deep-fried foods are furthering understanding of how these fats contribute to aging and development of human diseases such as atherosclerosis and cancer, according to Purdue University scientists. One group of dogs fed a highly-oxidized lipid diet and another group fed one with a moderate level of this fat type, both had reduced growth, bone formation and immune function, said John Turek, Purdue professor of basic sciences. This was the first study in dogs to assess the effects of oxidized lipids on growth, antioxidant status, bone development and immune function.

Study Finds Blood Cells Able to Switch Identity

Scientists have found a new wrinkle in the developmental biology dogma that cell differentiation occurs irreversibly as stem cells give rise to increasingly specialized types of offspring cells. The researchers have shown that certain mouse cells retain an ability to oscillate between very distinct blood cell types ? B-cells and macrophages ? long after what has been commonly regarded as the point of no return.