Researchers make breakthrough in understanding cause cancer development

A lab headed by a Saint Louis University researcher has made a major breakthrough that could lead to a better molecular understanding of cancer. Results published today in the Journal Molecular Cell by Ali Shilatifard, Ph.D., and colleagues show for the first time how a protein known to be involved in the development of cancer functions in normal cells. The research shows how the protein “Bre1” plays a pivotal role in determining how the protein “Rad6” functions in modification of chromosomal DNA. Also participating in this research was the lab of Dr. Mark Johnston at Washington University School of Medicine.