NewYork-Presbyterian Hospital/Weill Cornell Medical Center physician-scientists are presenting exciting new research at the 2009 American Transplant Congress in Boston from May 30 to June 3.
Dr. Sandip Kapur, chief of transplant surgery and director of kidney and pancreas transplant programs at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, and Dr. Manikkam Suthanthiran, chairman of the Department of Transplantation Medicine and chief of the Division of Nephrology and Hypertension at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, are both available for comment on the following studies and on other news from the conference.
Alterations in MicroRNA Predict Rejection and May Be Novel Treatment Target
[1016] Poster Session: Basic Mechanisms of Acute Rejection I
Sunday, May 31, 5:30 p.m.; Exhibit Hall C
Authors: Dany Anglicheau, Vijay Sharma, Ruchuang Ding, Aurélie Hummel, Catherine Snopkowski, Darshana Dadhania, Surya Seshan, Manikkam Suthanthiran
The authors have identified differences in the expression of microRNAs between patients who experienced kidney rejection and those with successful long-term transplants. MicroRNAs are a newly discovered group of genes that control a wide variety of biological process. The researchers found that rejection can be predicted with a greater than 95 percent accuracy by screening for the changes in expression of very few microRNAs. In addition to serving as a novel diagnostic test, microRNA profiles may predict the development of transplant rejection and response to anti-rejection treatment. Moreover, the researchers hope to develop safe and personalized treatment using microRNA profiles to guide therapy.
From Concept to Reality: Increasing Transplantation Through Donor Chains
[319] Concurrent Session 45: Kidney Living Donor Paired Exchange/Donor Chains
Monday, June 1, 4:12 p.m.; Room 302/304
Authors: David Leeser, Meredith Aull, Judith Hambleton, David Serur, Garet Hil, Darshana Dadhania, Marian Charlton, Sandip Kapur
Approximately one-third of kidney transplant candidates with the potential to receive a transplant from a living donor will be incompatible due to blood type or immune system reactivity against the donor. Registries such as the National Kidney Registry have been developed to match incompatible donor/recipient pairs with more acceptable donors and recipients. In addition, altruistic donors, who do not have an intended recipient, are entered into the registry to increase the pool of potential donors. This system has allowed NewYork-Presbyterian/Weill Cornell to transplant 70 percent of incompatible pairs.
Transplanting Islet Cells Without Use of Toxic Drugs
[154] Concurrent Session 22: Novel Methods of Immune Regulation in Islet Transplantation
Sunday, May 31, 4:12 p.m.; Room 312
Authors: Elaine Cheng, Raymond Weir, Mila Lagman, Vijay Sharma, Manikkam Suthanthiran, Hua Yang
Researchers will present their results demonstrating the ability of a specialized type of cells, called T regulatory cells, to protect pancreatic islet cell transplants in mice and eliminate the need for standard immunosuppressive drugs. Since the drugs currently used to treat islet cell transplantation are toxic to the islet cells themselves, a T regulatory cell-based treatment regimen in the clinic may have significant advantages over the current treatments.
Transplanting Single Kidneys From Donors Under 5 Years of Age Into Standard Adult Recipients: Can We Achieve Optimal Outcomes?
[92] Concurrent Session 13: Pediatric and DCD Donors
Sunday, May 31, 2:39 p.m.; Room 208
Authors: Vinod Balachandran, Meredith Aull, Maria Goris, Jose Figueiro, David Leeser, Sandip Kapur
Researchers will present their results showing that average-sized adults receiving a single kidney from pediatric donors less than five years of age have similar outcomes to adults receiving a kidney from an adult donor. Historically, adults receiving transplants from young donors were given both kidneys because it was thought that a single pediatric kidney could not provide adequate renal function for an adult. This practice has the potential to increase the organ donor pool.
Non-invasive Urine Test for Diagnosis of Most Common Kidney Transplant Complications
[122] Concurrent Session 17: Immune Monitoring: Chronic Allograft Damage and Chronic Humoral Rejection
Sunday, May 31, 4:48 p.m.; Room 309
Authors: Thangamani Muthukumar, Ruchuang Ding, Catherine Snopkowski, Aurélie Hummel, Vijay Sharma, Darshana Dadhania, Surya Seshan, Manikkam Suthanthiran, Dany Anglicheau
The authors will present their findings about the development and validation of a new gene-based urine test for the diagnosis of renal interstitial fibrous and tubular atrophy (scarring of the kidney transplant) — the most common cause of kidney transplant failure. Before now, an invasive biopsy test was the only way to diagnose the condition.
Older Living Donors Provides Excellent Outcomes After Kidney Transplantation
[532] Concurrent Session 74: Kidney Living Donor Outcomes I
Tuesday, June 2, 5:00 p.m.; Ballroom C
Authors: Vinod Balachandran, David Leeser, Meredith Aull, Marian Charlton, Jose Figueiro, David Serur, Joseph Del Pizzo, Sandip Kapur
Some transplant centers avoid accepting older living donors due to concerns over inferior kidney function in the recipient. The authors have shown that equivalent outcomes can be achieved with transplantation of kidneys from donors older than 50 years when compared with donors younger than 50. It was noted that kidney function was lower, though acceptable, in recipients of kidneys from donors over 70 years of age.
Predicting Kidney Function in Transplant Patients With BK Virus Infection
[1558] Poster Session: Strategies in Immune Monitoring
Monday, June 1, 5:30 p.m.; Exhibit Hall C
Authors: Darshana Dadhania, Catherine Snopkowski, Thangamani Muthukumar, Jun Lee, Vijay Sharma, Ruchuang Ding, Surya Seshan, Manikkam Suthanthiran
BK virus infection has emerged as a major complication in transplant recipients, and almost 50 percent of transplant patients with BK virus infection go on to lose their transplants. Until now, it has been difficult to predict which patients will have a bad outcome and those who will not. The authors have developed a new molecular test to identify patients at risk for disease progression.
Charlson Comorbidity Index Predicts Patient Survival Independent of Age Following Deceased Donor Renal Transplantation
[107] Concurrent Session 15: Donor/Recipient Factors and SCDs
Sunday, May 31, 4:48 p.m.; Room 210
Authors: David Leeser, Meredith Aull, Ryan Cauley, Jose Figueiro, Sandip Kapur
Charlson Comorbidty Index (CCI) scores may be a novel tool to assess whether kidney transplant candidates will do well after transplant. The authors found that patients with a higher CCI score have a higher risk of death and graft loss if they receive a donor organ from someone older and/or with comorbidties, but do well if they receive a standard donor organ.
Organ Transplantation at NewYork-Presbyterian Hospital
The organ transplantation program at NewYork-Presbyterian Hospital — which includes NewYork-Presbyterian Hospital/Weill Cornell, NewYork-Presbyterian Hospital/Columbia and The Rogosin Institute — is the most active program of its kind in the nation, offers comprehensive and personalized care for the heart, liver, pancreas, kidney and lung. With outcomes ranked among the nation’s best, the Hospital is dedicated to improving quality of life for its patients. NewYork-Presbyterian’s dedicated teams of surgeons and physicians are responsible for many significant advances made over the past several decades in transplant surgery and the maintenance of healthy organs. The Hospital has been on the forefront of developing and improving anti-rejection medications (immunosuppressants), minimally invasive surgery for living donors, genetic methods to detect transplant rejection, strategies to increase opportunities for donor matching, islet cell transplantation and the FDA-approved Left Ventricle Assist Device (LVAD) that functions as a bridge to transplantation for those waiting for a new heart.
NewYork-Presbyterian Hospital/Weill Cornell Medical Center
NewYork-Presbyterian Hospital/Weill Cornell Medical Center, located in New York City, is one of the leading academic medical centers in the world, comprising the teaching hospital NewYork-Presbyterian and Weill Cornell Medical College, the medical school of Cornell University. NewYork-Presbyterian/Weill Cornell provides state-of-the-art inpatient, ambulatory and preventive care in all areas of medicine, and is committed to excellence in patient care, education, research and community service. Weill Cornell physician-scientists have been responsible for many medical advances — including the development of the Pap test for cervical cancer; the synthesis of penicillin; the first successful embryo-biopsy pregnancy and birth in the U.S.; the first clinical trial for gene therapy for Parkinson’s disease; the first indication of bone marrow’s critical role in tumor growth; and, most recently, the world’s first successful use of deep brain stimulation to treat a minimally conscious brain-injured patient. NewYork-Presbyterian Hospital also comprises NewYork-Presbyterian Hospital/Columbia University Medical Center, NewYork-Presbyterian Morgan Stanley Children’s Hospital, NewYork-Presbyterian Hospital/Westchester Division and NewYork-Presbyterian Hospital/The Allen Pavilion. NewYork-Presbyterian is the #1 hospital in the New York metropolitan area and is consistently ranked among the best academic medical institutions in the nation, according to U.S. News & World Report. Weill Cornell Medical College is the first U.S. medical college to offer a medical degree overseas and maintains a strong global presence in Austria, Brazil, Haiti, Tanzania, Turkey and Qatar. For more information, visit www.nyp.org and www.med.cornell.edu.
