How NOV-002 treatment leads to gene expression

HOW NOV-002 treatment leads to gene expression changes in SKOV3 cancer cell lines
———-

NADPH oxidase genes are up-regulated by chronic NOV-002 treatment in SKOV3 cells

NOX5 – 13.3 fold NADPH oxidase, EF calcium binding domain 5
– produces superoxide
– activated by calcium

CYBA – 2.1 fold – Cytochrome b-245 alpha polypeptide; p22 PHOX
– 22 KD subunit of NADPH oxidase
– produces superoxide anion

NCF – 2.1 fold – Neutrophil cytosolic factor 1: p47 PHOX; NOX02
– 67 KD subunit of NADPH oxidase
– produces superoxide anion
———————————–
Other genes that are up-regulated by chronic NOV-002 treatment in SKOV3 cells

IL8 – 39 fold – interleukin 8
– CXC chemokine; medicator of inflammatory response
– Chemoatrractrant and angiogenic factor
– Induced by oxidative stress

VEGFA – 3.5 fold – Vascular endothelial growth factor A
– Angiogenic factor
– Induced by oxidative stress
– Activates NADPH oxidase resulting in superoxide production

JUN – 1.8 fold – Jun oncogenes
– Activation can lead to Apoptosis


The material in this press release comes from the originating research organization. Content may be edited for style and length. Have a question? Let us know.

Subscribe

One email, each morning, with our latest posts. From medical research to space news. Environment to energy. Technology to physics.

Thank you for subscribing.

Something went wrong.

Leave a Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.