How NOV-002 treatment leads to gene expression

HOW NOV-002 treatment leads to gene expression changes in SKOV3 cancer cell lines
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NADPH oxidase genes are up-regulated by chronic NOV-002 treatment in SKOV3 cells

NOX5 – 13.3 fold NADPH oxidase, EF calcium binding domain 5
– produces superoxide
– activated by calcium

CYBA – 2.1 fold – Cytochrome b-245 alpha polypeptide; p22 PHOX
– 22 KD subunit of NADPH oxidase
– produces superoxide anion

NCF – 2.1 fold – Neutrophil cytosolic factor 1: p47 PHOX; NOX02
– 67 KD subunit of NADPH oxidase
– produces superoxide anion
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Other genes that are up-regulated by chronic NOV-002 treatment in SKOV3 cells

IL8 – 39 fold – interleukin 8
– CXC chemokine; medicator of inflammatory response
– Chemoatrractrant and angiogenic factor
– Induced by oxidative stress

VEGFA – 3.5 fold – Vascular endothelial growth factor A
– Angiogenic factor
– Induced by oxidative stress
– Activates NADPH oxidase resulting in superoxide production

JUN – 1.8 fold – Jun oncogenes
– Activation can lead to Apoptosis

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