Low vitamin D levels linked to allergies in kids

February 24, 2011 ─ (BRONX, NY) ─ A study of more than 3,000 children shows that low vitamin D levels are associated with increased likelihood that children will develop allergies, according to a paper published in the February 17 online edition of the Journal of Allergy and Clinical Immunology. Researchers from Albert Einstein College of Medicine of Yeshiva University headed the study.

Researchers looked at the serum vitamin D levels in blood collected in 2005-2006 from a nationally representative sample of more than 3,100 children and adolescents and 3,400 adults. The samples are derived from the National Health and Nutrition Examination Survey (NHANES), a program of studies designed to assess the health and nutritional status of adults and children in the United States. The survey is unique in that it combines interviews, physical examinations and laboratory studies. One of the blood tests assessed was sensitivity to 17 different allergens by measuring levels of Immunoglobulin E (IgE), a protein made when the immune system responds to allergens.

When the resulting data was analyzed by Einstein researchers, no association between vitamin D levels and allergies was observed in adults. But for children and adolescents, low vitamin D levels correlated with sensitivity to 11 of the 17 allergens tested, including both environmental allergens (e.g., ragweed, oak, dog, cockroach) and food allergens (e.g., peanuts). For example, children who had vitamin D deficiency (defined as less than 15 nanograms of vitamin D per milliliter of blood), were 2.4 times as likely to have a peanut allergy than were children with sufficient levels of vitamin D (more than 30 nanograms of vitamin D per milliliter of blood).

The research shows only an association and does not prove that vitamin D deficiency causes allergies in children, cautioned Michal Melamed, M.D., M.H.S., assistant professor of medicine and of epidemiology & population health at Einstein and senior author of the study. Nevertheless, she said, children should certainly consume adequate amounts of the vitamin. “The latest dietary recommendations calling for children to take in 600 IU of vitamin D daily should keep them from becoming vitamin-D deficient,” she said.

The title of the paper is “Vitamin D levels and food and environmental allergies in the United States: Results from NHANES 2005-2006.”

Albert Einstein College of Medicine of Yeshiva University is one of the nation’s premier centers for research, medical education and clinical investigation. During the 2009-2010 academic year, Einstein is home to 722 M.D. students, 243 Ph.D. students, 128 students in the combined M.D./Ph.D. program, and approximately 350 postdoctoral research fellows. The College of Medicine has 2,775 fulltime faculty members located on the main campus and at its clinical affiliates. In 2009, Einstein received more than $155 million in support from the NIH. This includes the funding of major research centers at Einstein in diabetes, cancer, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Through its extensive affiliation network involving five medical centers in the Bronx, Manhattan and Long Island – which includes Montefiore Medical Center, The University Hospital and Academic Medical Center for Einstein – the College of Medicine runs one of the largest post-graduate medical training programs in the United States, offering approximately 150 residency programs to more than 2,500 physicians in training. For more information, please visit www.einstein.yu.edu