Insulin resistance in the liver is a major factor in the development of type 2 diabetes, and it is almost always associated with too much fat in the liver — a condition called non-alcoholic fatty liver disease (NAFLD).
The question of whether there’s a causal link between NAFLD and type 2 diabetes has been unclear. In recent studies, Yale professor of medicine and investigator of the Howard Hughes Medical Institute, Gerald Shulman has identified factors that cause the normal function of insulin in the liver to go awry in NAFLD. A new study pinpoints the final link between NAFLD and the changes in insulin and blood sugar that give rise to type 2 diabetes.
In this new study Shulman and his colleagues identified a single amino acid in the insulin receptor that undergoes phosphorylation (a process by which phosphate is added to an amino acid), causing liver insulin resistance in rodent models of NAFLD. “We were able to demonstrate the importance of this amino acid in causing liver insulin resistance associated with NAFLD by mutating this threonine amino acid to an alanine, which cannot undergo phosphorylation, and found that we could prevent hepatic insulin resistance despite the presence of fatty liver disease,” Shulman said.
This latest finding gets scientists a step closer to developing new therapies for type 2 diabetes that target the root molecular cause of insulin resistance, as opposed to virtually all current antidiabetic medications which lower blood glucose concentrations without reversing insulin resistance, he noted.
Other authors include Max C. Petersen, Anila K. Madiraju, Brandon M. Gassaway, Michael Marcel, Ali R. Nasiri, Gina Butrico, Melissa J. Marcucci, Dongyan Zhang, Abulizi Abudukadier, Xian-Man Zhang, William Philbrick, Stevan R. Hubbard, Michael J. Jurczak, Varman T. Samuel, and Jesse Rinehart.
Read the full study, published in the Journal of Clinical Investigation.
In July of 2015, it was discovered that I had type 2 diabetes. By the end of the month, I was given a prescription for Metformin. I stated the ADA diet and followed it completely for several weeks but was unable to get my blood sugar below 140. With no results to how for my hard work, I panicked and called my doctor. His response? Deal with it. I began to feel that something wasn’t right and do my own research. Then I found Rachel’s blog http://curediabetespro.gq/ . I read it from cover to cover and I started the diet and by the next morning, my blood sugar was 100. Since then, I have a fasting reading between the mid 70s and 80s. My doctor was so surprised at the results that, the next week, he took me off the Metformin. I lost 30 pounds in the first month and lost more than 6 inches off my waist and I’m able to work out twice a day while still having lots of energy. The truth is we can get off the drugs and help myself by trying natural methods.