Aging in Plants (or no aging in plants?)

My theory of aging is about predator-prey dynamics. By the broad definition, all animals are “predators”. They require another species to make food for them, and hence they are vulnerable to population overshoot. They can drive their food source to extinction by over-hunting or over-grazing, and then it’s curtains for the predator/animal. This creates a … Read more

Patrick Soon-Shiong on Cancer, Viruses, and Politics

This is a summary of an interview of Patrick Soon-Shiong, concerning cancer, various COVID treatments, and politics. This interview is 10 months old, but it’s new to me (via Dr Mercola). Patrick Soon-Shiong was a doctor, then a biochemical researcher. He sold two of his ideas to Big Pharma for billions of dollars, and has plowed that money … Read more

Bacteria against Cancer

A research team from the Japan Advanced Institute published a research paper this month describing an innovative and promising approach to cancer treatment. They report on a bacterial species extracted from the gut of the Japanese Tree Frog that demonstrated a 100% cure rate in a mouse model of human colon cancer. All the untreated … Read more

Review of Anti-Aging Drugs

  Since 2017, the DrugAge database has been a resource cataloguing longevity studies for many substances fed to animals in lab experiments. A preprint by Parish et al was recently posted to the bioRxiv website which assessed the quality of these various studies and sought to draw conclusions. Parish et al include a table of … Read more

SV40 and the Sorcerer’s Apprentice

SV stands for “Simian Virus”, a virus that infects monkeys. Viruses are adept at co-opting our cells’ metabolism, redirecting the native abilities of the cell to ends that benefit only the virus. One of the tricks that SV40 uses is called a promoter. Promoters turn genes on, so they become active. Background: (Almost) every cell in … Read more

Gary Ruvkun and the Science of Aging

Gary Ruvkun was awarded the Nobel Prize in Medicine today for establishing the importance of RNA as a signal molecule, independent of its role in transcribing nuclear DNA. Before he worked on RNA, Ruvkun made important contributions to theoretical understanding of aging in lab worms, C. elegans. In 1993, Cynthia Kenyon had found that incapacitating … Read more

Sex and the Single Paramecium

In Darwinian terms, sex is good for the community, bad for the individual. If this statement doesn’t make sense to you, perhaps you are thinking that sex is a part of reproduction, and reproduction is the very definition of Darwinian fitness. But sex is the sharing of genes. Reproduction is the process of creating new … Read more

Stochastic methylation clocks?

Methylation clocks have found their way into the community of aging research as a way to test anti-aging interventions without having to wait for mortality statistics. But methylation clocks are only useful for this purpose if aging is an epigenetic program, and most aging researchers still resist this paradigm. Just this year, some researchers have … Read more