It is known that teeth can protect themselves, to some extent, from attack by bacteria but that inflammation within a tooth can be damaging and, in extreme cases, lead to abscess or death of the tooth. New research published in BioMed Central’s open…
For antibiotics, the best way to beat bacterial defenses may be to avoid them altogether. Researchers at University of Pennsylvania School of Medicine have discovered that Cecropin A, a member of a family of antibiotic proteins produced by insects, may kill bacteria and avoid resistance by entering bacterial cells and taking control of their genetic machinery.
While most antibiotics kill bacteria by attacking critical enzyme systems, Cecropin A somehow slips inside the bacteria and turns specific genes on and off. The findings challenge conventional thinking on how these antibiotics function, and may aid in turning antimicrobial peptides like Cecropin A into therapeutic agents.
Researchers say they’ve found that people with atopic dermatitis, a.k.a. eczema, are susceptible to bacterial infections in their skin because their bodies don’t produce enough of two antimicrobial peptides. The findings show that while an allergic reaction can cause a rash, true eczema is all about infection. And medicines containing or inducing the peptides could be used to fight the disorder, which affects millions worldwide.