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New discovery could lead to vaccines for plague and bacterial pneumonias

Saranac Lake, N.Y. -- There is an ongoing battle in the "war on terror" that remains mostly unseen to the public -- a race between scientists working to develop a vaccine to protect against plague and the terrorists who seek to use plague as a ...

An important breakthrough by IRCM researchers in hematopoiesis and the development...

A team at the Institut de recherches cliniques de Montréal (IRCM) led by Dr. Tarik Möröy, President and Scientific Director of the institute and Director of the Hematopoiesis and Cancer research unit, will be publishing an important breakthrough ...

Scientists identify molecular gatekeeper of arthritis

Elimination of a molecular gatekeeper leads to the development of arthritis in mice, scientists report in a study published in the Journal of Experimental Medicine. The newly discovered gatekeeper is a protein that determines the fate -- survival o...

Immune cells may help deliver cancer vaccines for children

In a finding that could lay the groundwork for future cancer vaccines for children, cancer researchers working in cell culture have shown that modified immune cells can efficiently deliver genetic material to stimulate a desirable immune response. Researchers from The Children's Hospital of Philadelphia and the Abramson Family Cancer Research Institute at the University of Pennsylvania manipulated immune cells called CD40-activated B cells to carry RNA produced by tumors and viruses. The RNA, which carries genetic codes from DNA, was obtained either from tumor or viral proteins. The researchers adapted an approach used in research on adults to one more appropriate for children.

Staph study could help with treatment for lupus

Researchers have for the first time described a method that Staphylococcus aureus (staph) infection uses to inactivate the body's immune system. A protein produced by the staph bacteria causes previously healthy B cells -- a specialized cell of the immune system -- to commit suicide, a process called apoptosis. "By the targeted elimination of disease-causing B cells, properly dosed injections of SpA may have the potential to control the over-activity of the immune system that causes damage in autoimmune diseases like lupus and in certain cancers," said Gregg Silverman, M.D., UCSD professor of medicine and senior author of the paper.

Antibodies critical for fighting West Nile Virus infection

Researchers have found that immune cells called B cells and the antibodies they produce play a critical early role in defending the body against West Nile Virus. The results are published in the February issue of the Journal of Virology. Mice that lacked B cells and antibodies were completely unable to combat the virus. They developed serious brain and spinal-cord infection and ultimately died.

Study Finds Blood Cells Able to Switch Identity

Scientists have found a new wrinkle in the developmental biology dogma that cell differentiation occurs irreversibly as stem cells give rise to increasingly specialized types of offspring cells. The researchers have shown that certain mouse cells retain an ability to oscillate between very distinct blood cell types ? B-cells and macrophages ? long after what has been commonly regarded as the point of no return.

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