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World’s Oldest Monkeys May Explain Age-related Mental Decline

Scientists may have discovered why the brain’s higher information-processing center slows down in old age, affecting everything from language, to vision, to motor skills. The findings may also point toward drugs for reversing the process.
A brain chemical called GABA helps neurons stay finicky about which signals they respond to – a must for the brain to function at its peak. Certain neurons in very old macaque monkeys lose their pickiness, researchers have found, seemingly because they don’t get enough GABA. These results appear in the journal Science, published by the American Association for the Advancement of Science (AAAS).

Study finds addictive drugs all tweak same neurons in brain

Drug addicts may prefer some drugs over others, but their brains all have something in common. Whether it’s uppers or downers, addictive drugs tweak the same addiction-related neurons, causing them to become more sensitive, say researchers at Stanford University Medical Center. “What we have identified is a single change caused by drugs of abuse with different molecular mechanisms,” said researcher Robert Malenka.

Human Neural Stem Cells Can Become Dopamine-Making Brain Cells

Biologists have shown for the first time in the laboratory that they can convert some adult human neural stem cells to brain cells that can produce dopamine, the brain chemical missing in Parkinson’s disease. If the researchers can better understand the process and harness this ability, the work may someday lead to new strategies in treating neurodegenerative diseases such as Parkinson’s.