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Cocaine harms brain’s ‘pleasure center’

New research results strongly suggest that cocaine bites the hand that feeds it, in essence, by harming or even killing the very brain cells that trigger the “high” that cocaine users feel. This most comprehensive description yet of cocaine-induced damage to key cells in the human brain’s dopamine “pleasure center” may help explain many aspects of cocaine addiction, and perhaps aid the development of anti-addiction drugs. It also could help scientists understand other disorders involving the same brain cells, including depression.

Stem cells used to track and destroy brain tumor cells

Researchers in Los Angeles have combined a special protein that targets cancer cells with neural stem cells to track and attack malignant brain tumor cells. Glioblastoma multiforme, or gliomas, are a particularly deadly type of brain tumor. They are highly invasive with poorly defined borders that intermingle with healthy brain tissue, making them nearly impossible to remove surgically without catastrophic consequences. Furthermore, cells separate from the main tumor and migrate to form satellites that escape treatment and often lead to recurrence.