PHILADELPHIA — It took 12 years and a creation of a highly sophisticated transgenic mouse, but researchers at Kimmel Cancer Center at Jefferson have finally proven a long suspected theory: Inflammation in the breast is key to the development and p…
The research, unveiled at a press conference today (14 September 2010), shows that the watercress compound is able to interfere with the function of a protein which plays a critical role in cancer development.
As tumours develop they rapidly outg…
Use of a Vitamin A derivative in former smokers restored production of a crucial protein believed to protect against lung cancer development, researchers have found. Although they don’t have clear evidence that the three-month therapy using 9-cis retinoic acid (9-cis-RA) restored health to cells that were already precancerous, the researchers say the work demonstrates that “chemoprevention” of future lung cancer may be feasible. “The drug we used acts to reverse a genetic abnormality associated with development of lung cancer,” says Jonathan Kurie, M. D., an associate professor of medicine at the University of Texas M. D. Anderson Cancer Center. “The work is a proof of concept, suggesting that compounds like this may prove to have a protective effect against development of precancerous lesions.”
A lab headed by a Saint Louis University researcher has made a major breakthrough that could lead to a better molecular understanding of cancer. Results published today in the Journal Molecular Cell by Ali Shilatifard, Ph.D., and colleagues show for the first time how a protein known to be involved in the development of cancer functions in normal cells. The research shows how the protein “Bre1” plays a pivotal role in determining how the protein “Rad6” functions in modification of chromosomal DNA. Also participating in this research was the lab of Dr. Mark Johnston at Washington University School of Medicine.