A surgical technique appears to offer quick and effective relief for debilitating spinal fractures often suffered by patients with metastatic cancer, researchers reported at the 35th Congress of the European Society for Medical Oncology (ESMO) in Mil…
Researchers have generated a mouse model of a new type of tumor suppressor gene that triggers a rapidly advancing cancer that affects children. The discovery of the fast-onset cancers that result from inactivation of the gene and the technique used to generate the model will likely prove useful in studying genes involved in other forms of cancer.
In the race to cure cancer, researchers look for roadblocks that could stop cancer in its tracks, preventing it from spreading to other parts of the body. Scientists from Wisonsin may have found that blockade – an enzyme critical to the ability of cells to metastasize, a biological phenomenon by which cells migrate.
Cancer researchers in San Diego have developed a 3-step process in which human leukemia cells and neighboring immune-system T cells are manipulated together in the laboratory to create a powerful and specific cancer-killing cocktail. “For reasons that are not yet entirely clear, leukemia cells fail to trigger immune responses,” said the study’s senior author, Edward D. Ball, M.D., of the Rebecca and John Moores UCSD Cancer Center. “We have developed a method in which we induce the leukemia cell to change its behavior and stimulate the immune system. At the same time, we persuade the immune system to wake up and attack only the leukemia cells.” The details of this approach, known as adoptive immunotherapy or cellular therapy, are reported in the October issue of the journal Biology of Blood and Marrow Transplantation.