Scientists at Trinity College Dublin have made an important discovery concerning how fledgling cancer cells self-destruct, which has the potential of impacting on future cancer therapies. The Trinity research group, led by Smurfit Professor of Medi…
E2F5 is a member of the E2F transcription factor family, and plays a key role in cell growth and proliferation. Overexpression of E2F5 has been reported in various human cancers, but not in liver cancer, and its biological implication is largely unk…
St. Jude Children’s Research Hospital investigators have identified a novel structure in cells that serves as a control switch in the body’s system for eliminating damaged cells and also offers new therapeutic potential.
The findings provide fresh…
An article published in the journal BMC Medical Informatics and Decision Making describes the creation of the first comprehensive listing and classification of precancers, drawn from the medical literature. Using this classification, the precancers have been organized into groups that share similar biologic profiles and, hopefully, similar treatments. Precancers precede invasive cancers. They are localized changes in tissue ? lesions – identifiable by their morphologic structure. During carcinogenesis, when normal cells are transformed into cancerous cells, it is possible to identify precancers. Treating or removing precancerous cells at this early stage could prevent the prolonged, painful treatment and deaths of cancer sufferers. According to the authors of the article.
Scientists hunting for genes responsible for acute lymphoblastic leukemia have a new compass: a system that uses powerful genetic techniques in a zebrafish model. Researchers report they have created a zebrafish model that will help scientists pinpoint genes that accelerate or delay the spread of T cell acute lymphoblastic leukemia (ALL), a disease responsible for 400 deaths – about half of them, children – in the United States each year. The model may also provide a faster, more direct way of testing novel drugs against the disease.