imperial college london

Study of GM mosquitoes highlights difficulties facing malaria control technique

The first laboratory population study of genetically modified mosquitoes identifies issues that need to be faced in the task of turning mosquitoes from disease carriers into disease fighters. Scientists from Imperial College London report in Science today that populations including genetically modified mosquitoes quickly lose their test marker gene when they are bred with unmodified mosquitoes. The scientists say their results have several lessons for further work on developing GM mosquitoes, and they suggest a number of ways around the problems they have observed.

Researchers discover how leukaemia virus spreads through the body

Researchers have discovered the mechanism by which human T-lymphotropic virus type 1 (HTLV-1), the virus which causes adult T-cell leukaemia, spreads through the body. Previously it was not understood how HTLV-1 was able to spread between cells and pass between individuals, but according to research published today in Science, the virus spreads by subverting normal T-cell (a type of immune cell) behaviour, and without needing to release virus particles.

Structure of cog at the hub of metabolism reveals anti-ageing function

The structure of a key energy-releasing enzyme found in all animals is designed to minimise free radical production, an international team of researchers has reported in the journal Science. In a startling feat of structural biology, the team visualised the entire molecular structure of succinate dehydrogenase in the bacterium E. coli, allowing them to see for the first time how the protein’s three-dimensional shape helps prevent the formation of large quantities of these destructive oxygen atoms.

Researchers find link between improved memory and the use of neurofeedback

The results announced in the International Journal of Psychophysiology this month show a link between neurofeedback training and improved memory in a 40 person trial. Dr David Vernon, from Imperial College London at the Charing Cross hospital says: “Previous research has indicated that neurofeedback can be used to help treat a number of conditions including Attention Deficit Hyperactivity Disorder, epilepsy and alcoholism by training particular aspects of brain activity, but this is the first time we have shown a link between the use of neurofeedback, and improvements in memory.” Neurofeedback is a learning procedure that has been involved in treatments enabling participants to normalize behaviour, stabilize mood and improve their cognitive performance. It works by allowing people to watch their brain activity, and through this, find a way to correct or improve it.

Plasma probe scientists ready for Rosetta blast-off

Scientists who built and will control the instruments to investigate plasma changes around a comet describe their contribution to the ten year long mission at a pre-launch press briefing in London today. While the actual launch date for the European Space Agency’s Rosetta mission has yet to be confirmed, the scientists, engineers and technicians behind the plasma-detecting instruments on board the spacecraft are all ready to begin the journey to comet Wirtanen they hope will return a rich scientific bounty.

Protein gene linked to unexplored light detection system in eye

Researchers have discovered that melanopsin, a recently identified protein, plays a key role in a completely new light detection system in the eye. Professor Russell Foster, from Imperial College London at the Charing Cross Hospital comments: “It had long been assumed that the rod and cone cells of the retina are responsible for all light detection. However, over the last few years research from our group has led us to the inescapable conclusion that there is a third light detection system that has lain undiscovered over more than 100 years of intensive research on the eye. Although we have known of their existence for several years, it has proved difficult to discover much more about these new receptors”.

Tailor-made proteins manufactured in novel E. coli system

The prospect of using bacteria to manufacture complex human proteins for use in therapeutic drugs is a step closer thanks to new research published today in Science. Researchers from Switzerland and the UK report they have engineered the bacterium Escherichia coli to carry a vital piece of cell machinery that adds sugar molecules to newly synthesized proteins by a process known as glycosylation. The finding opens up the possibility of producing complex human proteins such as Factor VIII and the hormone erythropoietin, which stimulates the production of red blood cells by stem cells in bone marrow. Both these proteins, which require the addition of sugar molecules to function properly, are currently produced by culturing mammalian cells, which can be a costly and technically difficult process.

Scientists develop new blood test for heart disease

Scientists have developed a rapid new blood test which may help predict the likelihood of a heart attack. The research published in Nature Medicine shows how a new science called Metabonomics can be used to test for coronary artery disease, using minimally invasive procedures. The test, which only needs a few drops of blood, measures the magnetic properties of molecules in blood using high frequency radio waves, which are then analysed using an advanced computer programme capable of detecting abnormal patterns of signals associated with heart disease.