Curry pigment prevents alcohol-related liver disease in rats

Researchers have found that the yellow substance found in the pigment for curry prevents activation of a genetic factor leading to liver inflammation and necrosis. Despite numerous public education initiatives, alcohol abuse remains a leading cause of morbidity and mortality throughout the world. It is estimated that in the United States as many as 10 percent of men and three percent of women may suffer from persistent problems related to the use of alcohol. Alcohol affects many organ systems of the body, but perhaps most affected are the central nervous system and the liver. Almost all ingested alcohol is metabolized in the liver and excessive alcohol use can lead to acute and chronic liver disease.

Metastasis Gene May Be Useful for Diagnosis and Treatment of Liver Cancer

By analyzing the genes that are active in tumor cells, scientists may be able to predict whether the most common form of liver cancer, hepatocellular carcinoma, is likely to spread from its original site. Researchers at the National Cancer Institute (NCI), in collaboration with surgeons at the Liver Cancer Institute of Fudan University in Shanghai, report in a study published in Nature Medicine* that they have identified a pattern of gene activity that is unique to hepatocellular carcinoma cells that spread, or metastasize. Knowing whether a tumor is likely to metastasize can help physicians decide on the best treatment strategy for a patient.