Scientists Develop Colony of Mice That Fight Off Virulent Cancer

Scientists at the Comprehensive Cancer Center of Wake Forest University have developed a colony of mice that successfully fight off virulent transplanted cancers. “The mice are healthy, cancer-free and have a normal life span,” the 10-member team reported in the Proceedings of the National Academy of Sciences online edition to be published the week of April 28. The transplantation of the cancer cells in these special mice provokes a massive infiltration of white blood cells that destroy the cancer, said Zheng Cui, M.D., Ph.D., associate professor of pathology at Wake Forest University Baptist Medical Center and the lead scientist.

Adult stem cells shown to develop into all brain cell types

Researchers at the University of Minnesota provide evidence for the first time that stem cells derived from adult bone marrow and injected into the blastocyst of a mouse can differentiate into all major types of cells found in the brain. The results of the research are published as the lead article in the April 25, 2003 issue of Cell Transplantation. The potential of these adult stem cells, termed multipotent adult progenitor cells (MAPCs), were the subject of research reported in Nature in June 2002. The research reported this week in Cell Transplantation takes a specific look at the ability of MAPCs to develop into cells typically found in the brain.