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Neurodegenerative disorders

The mechanism of astrocytic autophagy plasticity plays a crucial role in AD. When the autophagy-regulating genes (LC3B and SQSTM1) in astrocytes are activated, Aβ is efficiently removed, which is important for cognitive recovery.

New brain cell cleaner: astrocytes raise possibility of Alzheimer’s disease treatment

Japanese researchers studied the effects of locally administered ASOs on mouse models of Parkinson's disease. Their research indicates that ASOs can help prevent the formation and spread of harmful alpha-synuclein aggregates in different brain regions, suggesting ASOs as a potential therapeutic strategy for preventing and controlling the progression of neurodegenerative diseases.

New Treatment Approach Shows Promise in Slowing Parkinson’s Disease Progression

Michael is checked by a nurse at SickKids before receiving gene therapy in a single-patient clinical trial for spastic paraplegia type 50 (SPG50).

Gene therapy halts progression of rare genetic condition in young boy

Dr Isaac Akefe and Professor Frederic Meunier in a QBI laboratory.

Fatty acids hold clue to creating memories

Cryo-EM structure of TAF15 amyloid filaments as discovered in patients with frontotemporal dementia

Protein found in brain linked to frontotemporal dementia

Retrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation

Gene Therapy Breakthrough: Navigating Parkinson’s Circuitry for Lasting Relief

Brain illustration

New biomarker, potential therapy for Multiple Sclerosis and related neuro disorders

Researchers found lion's mane mushroom improved brain cell growth and memory in pre-clinical trials. Image, UQ

Lion’s mane mushrooms magnify memory by boosting nerve growth

Illustration of human brain

How our brains turn into smarter disease fighters

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