Researchers identify ocular side effects of commonly prescribed drugs

Drugs commonly prescribed to osteoporosis and cancer patients may also cause serious ocular side effects in some cases. That’s the conclusion of a study published today by scientists at the Oregon Health & Science University Casey Eye Institute. This research is expected to alert physicians to monitor patients for eye problems not previously associated with the drug. The announcement may also help physicians identify problems earlier, therefore preventing long-term sight damage. Finally, this finding may prompt drug companies to update their product labeling, forewarning physicians and users.

Scientists locate, characterize key hormone involved in appetite control

Researchers have identified a key hormone involved in appetite control and demonstrated its effect on the brain. Scientists have shown that the hormone, called ghrelin, activates specialized neurons in the hypothalamus involved in weight regulation. Researchers believe this information could be used to develop drugs aimed at stimulating appetite in patients who have undergone extreme weight loss due to illness, a condition known as cachexia. Conversely, drugs aimed at limiting production of the hormone might be developed to reduce appetite for those battling severe obesity.

Mechanism to overcome Gleevec resistance demonstrated

Amid the glowing results for chronic myelogenous leukemia (CML) patients using Gleevec the past three years, the one reality check has been that a majority of the patients with advanced disease eventually relapse and die of the leukemia. An article to be published in the Dec. 15 issue of the journal Cancer Research shows that, in the lab, the molecular mutations that produce a resistance to Gleevec can be overcome. Brian Druker, M.D., Howard Hughes Medical Institute Investigator and JELD-WEN Chair of Leukemia Research at the Oregon Health & Science University Cancer Institute, and colleagues report that a compound called PD180970 successfully stopped the activity of several mutations found in patients who developed a resistance to Gleevec.