PHILADELPHIA – The gene for the protein p53 is the most frequently mutated in human cancer. It encodes a tumor suppressor, and traditionally researchers have assumed that it acts primarily as a regulator of how genes are made into proteins. No…
Jerusalem, March 1, 2011 — A pathway whereby bacteria communicate with each other has been discovered by researchers at the Hebrew University of Jerusalem. The discovery has important implications for efforts to cope with the spread of harmf…
DALLAS — March 1, 2011 — Researchers at UT Southwestern Medical Center have identified a signaling pathway in the brain that’s sufficient to induce cellular leptin resistance, a problem that decreases the body’s ability to “hear” that it is full…
AMES, Iowa – A protein pathway that may hold the secret to understanding Parkinson’s disease has been discovered and explained by Iowa State University researchers.
Anumantha Kanthasamy, a distinguished professor of biomedical sciences and t…
One of the most common congenital defects in humans — it is detected in approximately 0.5% of fetuses analyzed by routine antenatal sonography — is a kidney abnormality known as hydronephrosis. Hydronephrosis arises because the flow of urine f…
INDIANAPOLIS — A School of Science at Indiana University-Purdue University Indianapolis biophysicist has developed a new method to identify communication pathways connecting distant regions within proteins.
With this tool, Andrew J. Rader…
JUPITER, FL — January 25, 2011 — Embargoed by the journal Nature until January 30, 1 PM Eastern time — Scientists from the Florida campus of The Scripps Research Institute have identified a pathway in the brain that regulates an individual’s v…
CHAPEL HILL, N.C. — Researchers at the University of North Carolina at Chapel Hill have pinpointed a crucial function for a key player in the development of the nervous system. They found that this player — a protein called Erk — is necessary …
Stanford, CA — Plant biologists have discovered the last major element of the series of chemical signals that one class of plant hormones, called brassinosteroids, send from a protein on the surface of a plant cell to the cell’s nucleus. Although …
PHILADELPHIA — Overexpression or hyperactivation of ErbB cell-surface receptors drives the growth of many breast cancers. Drugs, like Herceptin, that block the receptors’ signals halt tumor progression in some patients. However, not all pati…
Scientists at the University of California, San Diego School of Medicine have described for the first time a key inhibitory role for the IL-1 signaling pathway in the human innate immune system, providing novel insights into human inflammatory bowel…