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‘Sharp’ elders use left brain to compensate for aging right

Elderly adults who perform as well as younger adults on certain cognitive tests appear to enlist the otherwise underused left half of the prefrontal cortex of their brain in order to maintain performance, neuroscientists have found. In contrast, elderly people who are not “high performers” on the tests resemble younger adults in showing a preferred usage of the right side of the prefrontal cortex.

Mimicking Brain’s ‘All Clear’ Tricks Rats into Not Feeling Scared

You say it's safe down there, but how do I know?Researchers funded by the National Institute of Mental Health (NIMH) have discovered a high tech way to quell panic in rats. They have detected the brain’s equivalent of an “all clear” signal, that, when simulated, turns off fear. The discovery could lead to non-drug, physiological treatments for runaway fear responses seen in anxiety disorders. Rats normally freeze with fear when they hear a tone they have been conditioned to associate with an electric shock. Dr. Gregory Quirk and Mohammed Milad, Ponce School of Medicine, Puerto Rico, have now demonstrated that stimulating a site in the front part of the brain, the prefrontal cortex, extinguishes this fear response by mimicking the brain’s own “safety signal.”