Combined hormone replacement therapy (HRT) increased the risk of stroke for postmenopausal women of all ages, whether or not they had hypertension. Researchers reported these findings, which are based on women studied in the Women’s Health Initiative, today at the American Stroke Association’s 28th International Stroke Conference. Information on subgroup analysis by age, race, hypertension status and baseline risk were not detailed when this major hormone study was halted last summer. “Estrogen plus progestin increased the risk of stroke in older and younger postmenopausal women, in those with and without high blood pressure and in those with no prior history of cardiovascular disease (CVD). Our finding is that this is absolutely not a strategy for primary prevention of cardiovascular disease.”