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Growing Human Skin in Laboratory Can Prematurely Age Cells

Children who receive laboratory-expanded sheets of their own skin to cover severe burns are saved from certain death, but their new skin can have the cellular age of an 80 year old, according to a study at Duke University Medical Center. The process of growing small patches of human skin into larger sheets, called tissue engineering, makes cells divide so many times that the skin becomes prematurely aged at a cellular level.

NASA hopes to improve computers with tiny carbon tubes on silicon

The life of the silicon chip industry may last 10 or more years longer, thanks to a new manufacturing process developed by NASA scientists. The novel method, announced in the April 14 issue of the journal Applied Physics Letters, includes use of extremely tiny carbon ‘nanotubes’ instead of copper conductors to interconnect parts within integrated circuits (ICs). Carbon nanotubes are measured in nanometers, much smaller than today’s components. A nanometer is roughly 10,000 times smaller than the width of an average human hair. ICs are very small groups of electronic components made on silicon wafers.

Researchers Determine Fundamental Mechanisms Involved in Immune Response

Scientists from the Howard Hughes Medical Institute and their colleagues have unraveled some of the fundamental mysteries about the genetic mechanisms that endow the immune system with its life-saving ability to generate specialized antibodies. Without genetic fine-tuning, antibodies would be relatively ineffective in finding a good match on the surface of viruses, parasites, and other potentially dangerous foreign pathogens. The findings also reveal the workings of a gene mutation process that can go awry, leading to the development of certain forms of cancer or allergic reactions.

Laser micro-scalpel yields biological insights into nature of tissue

Using a laser beam scalpel so fine it could inscribe words on the surface of a fly egg, researchers have snipped their way to a new understanding of a key process in a fruit fly’s embryonic development. The process, called dorsal closure, is the complex mechanism by which the embryonic skin of the fruit fly Drosophila knits itself together to protect its innards from the outside world. Understanding this seemingly arcane process is important because dorsal closure uses molecular and cellular mechanisms very similar to those involved in wound-healing as well as those that can go awry in humans to produce the spinal malformation spina bifida.

Duke Implements Additional Transplantation Safeguards

As a result of a blood type mismatch that occurred during the Feb. 7, 2003 heart-lung transplant for Jesica Santillan, Duke University Hospital has implemented additional safeguards that will improve the safety of the organ transplantation process.
“Every effort is being made to save Jesica’s life,” said William Fulkerson, M.D., CEO of Duke Hospital. “Our primary concern has always been for Jesica and her family. This was a tragic error, and we accept responsibility for our part. This is an especially sad situation since we intended this operation to save the life of a girl whose prognosis was grave. Jesica continues to remain at the top of the national organ donation list.

Eds: Jesica Santillan received a new heart transplant that was reportedly functioning unaided Thursday afternoon.

Self-control comes in limited quantities, must be replenished

Self-control, whether used to pass up the office cookie plate or to struggle against temptations like alcohol and tobacco, operates like a renewable energy source rather than a learned skill or an analytical thought process, according to new research.
Individuals had less physical stamina and impulse control and increased difficulty with problem-solving activities after completing a variety of tasks that required some measure of self-control, according to Roy F. Baumeister, Ph.D., of Florida State University.