MALVERN, PA — February 10, 2011 — Promedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic and inflammatory diseases, announced today the publication of collaborative research in the International Jour…
ANN ARBOR, Mich. — A diagnosis of idiopathic pulmonary fibrosis is not much better than a death sentence, given a survival rate averaging 4 to 6 years as the disease robs its victim of the ability to breathe.
But researchers at the University of…
First- or second-hand exposure to cigarettes can lead to a variety of diseases, including tissue destruction found in pulmonary emphysema and osteoporosis. Also included among cigarette smoking-induced diseases are disorders in which an excessive deposition of fibrotic scar occurs, such as with atherosclerosis and idiopathic pulmonary fibrosis. Collagen is the major protein of the white fibers found in connective tissue, cartilage, and bone.
Inflammation is usually a normal and beneficial response by the body to tissue injury or infection. But sometimes it can spiral out of control and lead to serious complications and diseases including pulmonary fibrosis, asthma and inflammatory bowel disease. Researchers have uncovered a mechanism that regulates the inflammatory response during tissue repair, providing the first specific molecular targets for developing ways to prevent highly destructive and potentially fatal inflammatory reactions.