school of medicine

New Tongue Reconstruction Methods Help Patients with Mouth Cancer

Surgeons have developed new techniques for reconstructing the tongue during surgery for mouth cancer. The researchers found that the new methods often restore a patient’s ability to articulate speech and swallow normal food. The findings are published in the December issue of the Archives of Otolaryngology. “As surgeons, we are most concerned about removing all of the cancer, but we also want to preserve the person’s quality of life,” says lead author Bruce H. Haughey, M.D., associate professor of otolaryngology. “This work strives to improve both.”

Leukemia-Related Protein is a Master Editor of the ‘Histone Code’

Rearrangements of the mixed lineage leukemia gene, MLL, are associated with aggressive leukemias in both children and adults. Researchers at the University of Pennsylvania School of Medicine have found that one portion of the MLL protein is an enzyme that “edits” the so-called histone code, a series of modifications to proteins associated with DNA that influence how and when certain genes are turned on and off. Their findings are presented in the November issue of Molecular Cell.

Firefly Light Illuminates Course of Herpes Infection in Mice

Researchers are using a herpes virus that produces a firefly enzyme to illuminate the virus’s course of infection in mice and to help monitor the infection’s response to therapy. “This study demonstrates the feasibility of monitoring microbial infections in living animals in real time,” says study leader David A. Leib. “The technique enables us to follow an infection over time as it progresses and resolves, and we can do this repeatedly using the same animal.”

Smallpox immunity lasts longer than thought

A new study suggests smallpox vaccine immunity may last far longer than expected. Scientists had believed that the vaccine generally only conferred protection from the deadly virus for about a decade. But a study released this week found evidence that people may be covered for 35 years or more, meaning many Americans could retain some level of immunity. The study looked at blood samples from laboratory workers who had been immunized in the last five years and those who had been vaccinated up to 35 years earlier.