Studying mice, scientists have successfully prevented a molecular event in brain cells that they’ve found is required for storing spatial memories. Unlike regular mice, the engineered rodents quickly forgot where to find a resting place in a pool of water, the researchers report in the March 7 issue of the journal Cell. The experiments are believed to be the first to prove that subtly altering the chemistry of a certain protein can profoundly affect a brain cell’s ability to respond to external stimulation, a process called neuronal plasticity, long thought to underlie learning and memory.