tumor suppressor gene
Researchers create ‘scoring system’ for PTEN mutation testing
Monday, January 10, 2011 — Cleveland — Researchers have discovered a method for more precise identification of individuals who should undergo testing for genetic mutations of the tumor suppressor gene PTEN, which associates with a variety of con…
Researchers discover genetic predisposition for breast, kidney cancers
Researchers at Cleveland Clinic’s Genomic Medicine Institute have revealed multiple genetic discoveries that may permit easier diagnosis and disease management for Cowden syndrome patients who are predisposed to breast and kidney cancer.
The rese…
Death, miscarriage linked to genetic mutation
Scientists have discovered that the genetic mutation that causes the childhood cancer retinoblastoma routinely triggers fetal death and miscarriage in laboratory animals by disrupting the normal functions of the placenta, a finding that may force researchers to reevaluate the powerful Rb gene and the role it plays in causing cancer.
Researchers Identify Cause of Aggressive Childhood Cancer
Researchers have generated a mouse model of a new type of tumor suppressor gene that triggers a rapidly advancing cancer that affects children. The discovery of the fast-onset cancers that result from inactivation of the gene and the technique used to generate the model will likely prove useful in studying genes involved in other forms of cancer.