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Where the fat’s at

In real estate, location is everything. The same might be said of lipids — those crucial cellular fats and oils that serve as building blocks for cells and as key energy sources for the body.
In a paper published in the September issue of…

Fruit fly protein found to aid healing in mamals

Biologists at the University of California, San Diego have determined that a protein essential for the normal embryonic development of fruit flies is also used by mammals to assist in the timely healing of cuts and lacerations. Their discovery, detailed in the June 3 issue of the journal Developmental Cell, provides new insight for scientists into the molecular mechanisms responsible for wound healing in humans and may one day lead to the design of new drugs for individuals whose healing is compromised.

Men, women both crazy jealous

Men are from Mars and women are from Venus, or so we’ve been told, and when it comes to jealousy this is especially true. Men, psychologists have long contended, tend to care more about sexual infidelity while women usually react more strongly to emotional infidelity. This view has long been espoused by evolutionary psychologists who attribute these gender differences to natural selection, which, they say, encouraged the sexes to develop different emotional reactions to jealousy. However, a recent research paper published in Personality and Social Psychology Review by Christine Harris, a psychologist with the Center for Brain and Cognition at the University of California, San Diego, casts serious doubts on this view of gender differences on jealousy and argues that more men and women appear to view sexual and emotional jealousy in the same light.

Researchers ID staph trick to kill off healthy cells

The method that Staphylococcus aureus (staph) infection uses to inactivate the body’s immune response and cause previously healthy B cells to commit suicide, is described for the first time by researchers at the University of California, San Diego (UCSD) School of Medicine. Normally, B cells mount an early defense against invading bacteria. From this immunologic experience, memory B cells are developed with the ability to quickly recognize these antigens and destroy the bacteria if they return in the future. When staph infections occur, however, this important process for immune defense can be corrupted.

New technique ID's parts of brain most crucial to 'normal' functioning

A team of researchers has developed a novel new brain imaging technique that produces maps that “light up” the relationship between the severity of a behavioral deficit and the voxels (similar to pixels in computer images) in the brain that contribute the most to that deficit. Discovery of the new technique, known as Voxel-based Lesion-Symptom Mapping (VLSM) will give researchers an invaluable new tool for pinpointing the specific areas of the brain that are most crucial for normal functioning during critical brain activities, starting with the measures of language comprehension and production that were used for the first demonstration in Nature Neuroscience, but moving on to many different language and non-language functions.

Researchers develop flexible, biocompatible polymers — with optical abilities

Researchers have discovered how to transfer the optical properties of silicon crystal sensors to plastic, an achievement that could lead to the development of flexible, implantable devices capable of monitoring the delivery of drugs within the body, the strains on a weak joint or even the healing of a suture. The discovery is detailed in the March 28 issue of Science by a team that pioneered the development of a number of novel optical sensors from silicon wafers, the raw starting material for computer chips.

Body's Own Antibodies May Drive New Strains of HIV

Scientists in California have provided the first detailed look at how human antibodies, proteins critical for the body’s defense against invading pathogens, may actually drive human immunodeficiency virus (HIV) to mutate and escape detection by the immune system. The findings, reported online March 18 in the Proceedings of the National Academy of Sciences, may be key in efforts to develop an effective AIDS vaccine.

Gene therapy cuts levels of Alzheimer's protein

A molecule that naturally degrades a protein linked to Alzheimer’s disease appears to reduce the levels of that protein by nearly 50 percent when delivered by gene therapy, researchers at the Salk Institute and UC San Diego have found in collaboration with researchers at the University of Kentucky. The findings appear in the March 15 issue of the Journal of Neuroscience.

Sapphire/slammer worm shatters previous Internet speed records

A team of network security experts in San Diego, Eureka and Berkeley, Calif., has determined that the computer worm that attacked and hobbled the global Internet 11 days ago was the fastest computer worm ever recorded. In a technical paper released today, the experts report that the speed and nature of the Sapphire worm, also called Slammer, represent significant and worrisome milestones in the evolution of computer worms. Computer scientists at the University of California, San Diego and its San Diego Supercomputer Center (SDSC), Eureka-based Silicon Defense, the University of California, Berkeley, and the nonprofit International Computer Science Institute in Berkeley, found that the Sapphire worm doubled its numbers every 8.5 seconds during the explosive first minute of its attack.