ucla neuropsychiatric institute

Study challenges bipolar depression treatment guidelines

A study led by a UCLA Neuropsychiatric Institute researcher challenges standard treatment guidelines for bipolar depression that recommend discontinuing antidepressants within the first six months after symptoms ease. Study participants treated under the guidelines relapsed at nearly twice the rate of those who continued taking antidepressants in conjunction with their mood stabilizer medication during the first year after remission of acute bipolar depression. The researchers found no increased risk of manic relapse in those who continued the medication for one year.

Physical Mimicry of Others Jump-starts Key Brain Activity

A child falls from his bicycle and his father winces. A bride says “I do” and the maid of honor grins from ear to ear. A mother frowns with displeasure and her infant son frowns back. UCLA neuroscientists using functional magnetic resonance imaging (fMRI) are the first to demonstrate that empathetic action, such as mirroring facial expressions, triggers far greater activity in the emotion centers of the brain than mere observation.

10 Keys to Recovery From Schizophrenia

UCLA Neuropsychiatric Institute researchers have identified 10 key factors to recovery from schizophrenia. The findings open opportunities to develop new treatment and rehabilitation programs and to reshape the negative expectations of many doctors, patients and their families. Based on analyses of the professional literature and the cases of 23 schizophrenia patients who successfully returned to work or school with their symptoms under control, the findings appear in the November 2002 edition of the International Review of Psychiatry.

Genetic Clash With Mother Doubles Child’s Schizophrenia Risk

Scientists have discovered that infants possessing a cell protein called Rhesus (Rh) factor that their mothers lack are twice as likely to develop schizophrenia in young adulthood. Reported in the December issue of the peer-reviewed American Journal of Human Genetics, the study suggests that the gene that codes for Rh factor is to blame for the higher risk. “Previous studies reported a link between mothers and infants who are Rh-incompatible and a higher rate of schizophrenia in the children later in life,” said Dr. Christina Palmer, a research scientist at the UCLA Neuropsychiatric Institute. “Our research is the first to take a genetic approach to examining this increased risk.”

Geneticists Find Location of Major Gene in ADHD; Also Linked to Autism

Researchers in Los Angeles have localized a region on chromosome 16 that is likely to contain a risk gene for Attention Deficit Hyperactivity Disorder, the most prevalent childhood-onset psychiatric disorder. The scientists say their finding suggest that the suspected risk gene may contribute as much as 30 percent of the underlying genetic cause of ADHD and may also be involved in a separate childhood onset disorder, autism.