Study challenges bipolar depression treatment guidelines

A study led by a UCLA Neuropsychiatric Institute researcher challenges standard treatment guidelines for bipolar depression that recommend discontinuing antidepressants within the first six months after symptoms ease. Study participants treated under the guidelines relapsed at nearly twice the rate of those who continued taking antidepressants in conjunction with their mood stabilizer medication during the first year after remission of acute bipolar depression. The researchers found no increased risk of manic relapse in those who continued the medication for one year.

UCLA finishes inquiry into prof's malaria-HIV research involvement

On March 30 the UCLA Medical Institutional Review Board (MIRB) issued its determination regarding a complaint about Dr. John Fahey and allegations that he participated in malariotherapy research at UCLA. The MIRB determined that Fahey, while not personally involved in the clinical trials, was involved in evaluating data and biological samples brought to UCLA from China by Dr. Xiao Peng Chen under the Fogarty International Program. Since Chen’s work was performed as part of the Fogarty Program at UCLA and was under Fahey’s supervision, the MIRB determined that Fahey was engaged in human subjects research. Chen had tested a theory that infecting HIV-positive patients with malaria could help the patient’s body fight off the AIDS-causing disease.

Physical Mimicry of Others Jump-starts Key Brain Activity

A child falls from his bicycle and his father winces. A bride says “I do” and the maid of honor grins from ear to ear. A mother frowns with displeasure and her infant son frowns back. UCLA neuroscientists using functional magnetic resonance imaging (fMRI) are the first to demonstrate that empathetic action, such as mirroring facial expressions, triggers far greater activity in the emotion centers of the brain than mere observation.

Quantum Dots Used to 'Draw' Circuits for Molecular Computers

By using tiny quantum dots to create trails of altered molecules, UCLA researchers are developing a method of producing nanoscale circuitry for the molecular computers of the future that will use molecular switches in place of transistors.
“This technology, although still in the unpublished, proof-of-concept stage, could eventually lead to a relatively inexpensive means of patterning interconnections between the logic gates of a molecular computer,” according to Harold G. Monbouquette, professor of chemical engineering at UCLA’s Henry Samueli School of Engineering and Applied Science, who leads the team.

Two brain systems tell us to breathe

Until now, scientists believed that a single area in the brain generated breathing rhythm, enabling breathing to speed up or slow down to adapt to the body’s activity and position. But UCLA neurobiologists have discovered that two systems in the brain interact to generate breathing rhythm — a finding that may translate into better treatment for sleep apnea and sudden infant death syndrome. The journal Neuron reported the findings in its March 6 issue.

Common Acne Treatment Stops Blindness in Animal Model

Administering Accutane, a drug commonly used to treat acne, UCLA researchers have successfully stopped the accumulation of toxic pigments in the eyes of animals with a genetic defect similar to Stargardt’s macular degeneration. The UCLA team gave a daily injection of Accutane to mimic the effect of constant light deprivation and the results proved dramatic. These toxic pigments, called lipofuscin, are responsible for the visual loss in patients with Stargardt’s disease.

Pain killers may dissolve Alzheimer's disease plaques

In a breakthrough study, scientists have found that common painkillers such as ibuprofen and naproxen may actually dissolve the brain lesions — or amyloid plaques — that are one of the definitive hallmarks of Alzheimer’s disease. The findings are reported in the March 31 issue of Neuroscience. Principal investigator Jorge R. Barrio, professor of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA, has used FDDNP, a new chemical marker developed in his laboratory at UCLA, to visually zero in on the brain lesions present in Alzheimer’s disease. He discovered that common over-the-counter pain medications — known as non-steroidal anti-inflammatory drugs — bind to amyloid plaques, and may help dissolve existing plaques and prevent the formation of new ones.