Leukemia-Related Protein is a Master Editor of the ‘Histone Code’

Rearrangements of the mixed lineage leukemia gene, MLL, are associated with aggressive leukemias in both children and adults. Researchers at the University of Pennsylvania School of Medicine have found that one portion of the MLL protein is an enzyme that “edits” the so-called histone code, a series of modifications to proteins associated with DNA that influence how and when certain genes are turned on and off. Their findings are presented in the November issue of Molecular Cell.

Electronic Nose Detects Pneumonia in Critically Ill Patients

A team of researchers from Pennsylvania say an electronic nose – a relatively new version of a sensor previously used in the food, wine and perfume industries – can quickly and accurately diagnose pneumonia in critically ill, mechanically ventilated patients.

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