The experiences of millions of people have proved that antidepressants work, but only with the advent of sophisticated imaging technology have scientists begun to learn exactly how the medications affect brain structures and circuits to bring relief from depression. Researchers at UW-Madison and UW Medical School recently added important new information to the growing body of knowledge. For the first time, they used functional magnetic resonance imaging (fMRI)–technology that provides a view of the brain as it is working–to see what changes occur over time during antidepressant treatment while patients experience negative and positive emotions.