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Electrophoresis of RNA, avian imaging featured in June's Cold Spring Harbor Protocols

COLD SPRING HARBOR, N.Y. (Tues., June 1, 2010) -- Gel electrophoresis is one of the most important and frequently used techniques in RNA analysis. Electrophoresis is used for RNA detection, quantification, purification by size and quality assessment. Gels are involved in a wide variety of methods including northern blotting, primer extension, footprinting and analyzing processing reactions. The two most common types of gels are polyacrylamide and agarose. Polyacrylamide gels are used in most applications and are appropriate for RNAs smaller than approximately 600 nucleotides (agarose gels are preferred for larger RNAs). "Polyacrylamide Gel Electrophoresis of RNA" describes how to prepare, load and run polyacrylamide gels for RNA analysis. The article is featured in the June issue of Cold Spring Harbor Protocols and is freely available on the journal's website. It is part of a suite of basic RNA protocols included in this month's issue that provide an early preview of the forthcoming RNA: A Laboratory Manual due later this year from Cold Spring Harbor Laboratory Press. The rapid pace of technological progress in biological imaging has provided great insight into the processes of embryonic development. But for higher organisms with opaque eggs or internal development, optical access to the embryo is limited. While various embryonic culture methods are available, vertebrate development is best studied in an intact embryo model, one in which the natural environment has not been disrupted. In the June issue of Cold Spring Harbor Protocols, Paul Kulesa and colleagues from the Stowers Institute for Medical Research present "In Ovo Live Imaging of Avian Embryos," a detailed set of instructions for time-lapse imaging of fluorescently labeled cells within a living avian embryo. During the procedure, a hole is made in the shell, and a Teflon membrane that is oxygen-permeable and liquid-impermeable is used to provide a window for visualization of the embryo via confocal or two-photon microscopy. Imaging can take place for up to five days without dehydration or degradation of the normal developmental environment. As one of June's featured articles, the protocol is freely available on the journal's website. About Cold Spring Harbor Protocols: Cold Spring Harbor Protocols (www.cshprotocols.org) is a monthly peer-reviewed journal of methods used in a wide range of biology laboratories. It is structured to be highly interactive, with each protocol cross-linked to related methods, descriptive information panels, and illustrative material to maximize the total information available to investigators. Each protocol is clearly presented and designed for easy use at the bench -- complete with reagents, equipment, and recipe lists. Life science researchers can access the entire collection via institutional site licenses, and can add their suggestions and comments to further refine the techniques. About Cold Spring Harbor Laboratory Press: Cold Spring Harbor Laboratory Press is an internationally renowned publisher of books, journals, and electronic media, located on Long Island, New York. Since 1933, it has furthered the advance and spread of scientific knowledge in all areas of genetics and molecular biology, including cancer biology, plant science, bioinformatics, and neurobiology. It is a division of Cold Spring Harbor Laboratory, an innovator in life science research and the education of scientists, students, and the public. For more information, visit www.cshlpress.com.

Jun 1, 2010

Brain & Behavior

Developer preview of Kamra, the first open standards-based mobile AR browser, at ARE2010

The Georgia Institute of Technology announces the release of the developer preview of Kamra, the first mobile augmented reality (AR) browser for the KHARMA (KML/HTML Augmented Reality Mobile Architecture) development platform based on open Web standards. The developer preview will be released at ARE2010 - Augmented Reality Event in Santa Clara, CA June 2. The release of Kamra for the iPhone in the iTunes Store is expected before the end of June. What Kamra is: The first mobile open standards browser that overlays information from multiple website channels simultaneously onto the user's phone. Kamra allows any content that can be displayed on Mobile Safari to be placed into the physical environment using standard KML. By being built on top of open Web technologies and standards, Kamra allows developers to produce a full range of collaborative applications. Kamra gives authors the freedom to customize the browser interface behavior for their own channels. Kamra lets users create and distribute content from their own hosted websites or through filters that generate KML. Future releases of Kamra will support marker tracking, HTML5 video and a range of 3-D content. The Kamra development team is led by Blair MacIntyre, associate professor in the School of Interactive Computing and faculty member at the GVU Center at Georgia Tech. Alex Hill, postdoctoral fellow within the Augmented Environments Lab in the School of Interactive Computing, will also be present at the demonstrations. The Kamra project is sponsored by Alcatel-Lucnet as part of their University Innovations Program. Kamra will be displayed on June 2 at 7 p.m. in the main theater as part of "The Auggies" session. It will also be displayed on June 3 at 2:30 p.m. at the panel session "Developing AR Games."

Jun 1, 2010

Health

After the oil spill: New research sheds light on coral susceptibility to environmental stress

Bethesda, MD -- Much attention has been paid to the fate of wildlife living on and above the Gulf of Mexico's surface. Now, a new research study published in the June 2010 print issue of the FASEB Journal (http://www.fasebj.org) looks toward the seafloor to explain coral susceptibility to disease outbreaks when they encounter environmental stress and to set the stage for understanding exactly what type of undersea environment is necessary to promote coral health and growth after the oil spill cleanup. In addition, this research also opens doors for the development of new tools that can assess the health of corals, which is important when trying to establish manmade reefs or to save ones that already exist. "We hope this study will highlight the need to maintain favorable environmental conditions on reefs to maximize the functioning of coral immune mechanisms and avert outbreaks of coral disease and bleaching," said Caroline Palmer, one of the researchers involved in the work who is from the Australian Research Council Centre of Excellence for Coral Reef Studies and School of Marine and Tropical Biology at James Cook University in Queensland, Australia. "Otherwise, declining environmental conditions associated with extractive activities, deteriorating water quality and a changing climate will threaten the long term persistence of corals and coral reefs, which support millions of lives worldwide through fisheries, tourism, and coastal protection amongst other functions." Palmer and colleagues sampled several coral species from the Great Barrier Reef to determine whether a suite of cellular and biochemical mechanisms of immunity were active. Using histological techniques they documented the presence and area of melanin-containing granular cells and the activity of specific enzymes as measures of oxidative damage and repair. Then the scientists investigated the relationship between coral immunity and disease and susceptibility to by analyzing the data on the activity of innate immunity in conjunction with published data on coral species' susceptibilities to oxidative bleaching and disease. Results suggest that different coral species invest different amounts of resources in immunity and defense, which may explain differences in the susceptibility to negative environmental impacts. "You don't have to be a marine biologist to know that the Gulf oil spill is an environmental disaster of the first order. Stuff leaching from the ocean floor is the worst environmental challenge a coral reef can face," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "But with luck, and with marine biology to explain how coral reefs survive, we can begin to get the Gulf ecosystems back on track sooner rather than later." According to the National Oceanic and Atmospheric Administration, "Corals that are spawning at the time of an oil spill can be damaged because the eggs and sperm, which are released into the water at very precise times, remain at shallow water depths for various times before they settle. Thus, in addition to compromising water quality, oil pollution can disrupt the long-term viability and reproductive success of corals, rendering them more vulnerable to other types of disturbances. In western Australia and the Flower Garden Banks of the northern Gulf of Mexico, spawning occurs in late summer or fall." Receive monthly highlights from the FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal (http://www.fasebj.org) is published by the Federation of the American Societies for Experimental Biology (FASEB). The journal has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century and is the most cited biology journal worldwide according to the Institute for Scientific Information. FASEB comprises 23 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB enhances the ability of scientists and engineers to improve -- through their research -- the health, well-being and productivity of all people. FASEB's mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy. Details: Caroline V. Palmer, John C. Bythell, and Bette L. Willis. Levels of immunity parameters underpin bleaching and disease susceptibility of reef corals. FASEB J. 2010 24: 1935-1946. doi: 10.1096/fj.09-152447 ; http://www.fasebj.org/cgi/content/abstract/24/6/1935

Jun 1, 2010

Health

Acceptance, social support, and educational access provide safety net for former child soldiers

Washington, DC, 31 May 2010 -- The Child Soldiers Global Report 20081 estimates that more than 300,000 children are engaged as soldiers around the globe, and more children are recruited every year in ongoing and new conflicts. Although a number of multinational coalitions are aligned to stop the recruitment of child soldiers, some countries persist in not only the recruitment of children but also in exposing children to both the psychological and physical dangers associated with combat. In the June issue of the Journal of the American Academy of Child and Adolescent Psychiatry, Harvard researchers report on the mental health outcomes of former child soldiers in Sierra Leone, finding that community acceptance, social support and school attendance can help mitigate the damaging influences of the children's wartime experiences and post-conflict stigma. The article, titled "Sierra Leone's Former Child Soldiers: A Longitudinal Study of Risk, Protective Factors, and Mental Health," draws on a longitudinal study of 260 male and female former child soldiers in Sierra Leone, ages 10-17 at the start of the study. 2 Betancourt and colleagues evaluated these youth at three time points in order to determine the long-term course of internalizing and externalizing problems and adaptive/prosocial behaviors, and investigate whether post-conflict factors contributed to adverse or resilient mental health outcomes. Virtually all of the subjects were children who were recruited by force or abduction to join the Revolutionary United Front (RUF), the rebel force which was one of the main actors in the 11-year civil war in Sierra Leone. At the time of the first evaluation (2002) 55.3% of the youth lived with a least one biological parent, although the percentage decreased to 34.1% by the third evaluation (2008). In describing the characteristics of the participants, the investigators state, "Youth joined the rebels at a mean age of 10.3 years and remained an average of 4.1 years. Participants had witnessed an average of 6.2 war-related violent events. Forty-five percent of girls and 5% of boys reported being raped during their time with the rebels. More than a quarter of the sample (26.9%, n=70) reported having killed or injured others during the war." Investigators used a variety of standard measures to evaluate mental health outcomes, including the Post-War Adversities Index and the Child Posttraumatic Stress Disorder Reaction Index, and locally-derived assessments, such as a scale of Community Acceptance. The findings demonstrated that increases in externalizing behavior were associated with both killing/injuring others during the war and post-conflict stigma. Additionally, high baseline levels of internalizing problems were associated with surviving rape while increases in these types of problems were associated with younger involvement in armed groups and with social and economic hardships. Additionally, the article reports that long-term well being for child soldiers can be mitigated by post-conflict factors. In particular, increases in community acceptance exerted a positive influence on all outcomes investigated. For instance, with increasing levels of acceptance, the youth demonstrated significant improvements in both externalizing and internalizing behaviors. Social support, school access, and increased community acceptance were also associated with increases in prosocial and adaptive behaviors. In the JAACAP article, Betancourt and colleagues state, "Based on our findings, we suggest that post-conflict adversities and resources must be given closer attention in both research and service delivery. Such understanding of the impact of multiple war-related and post-conflict factors is important for identifying appropriate intervention targets. The results of this study emphasize the importance of investing in longer-term (i.e., beyond the immediate post-conflict period) approaches to monitoring and supporting the wellbeing of war-affected youth." Notes to Editors This study was funded by the United States Institute of Peace, USAID/DCOF, Grant #1K01MH077246-01A2 from the National Institute of Mental Health, the International Rescue Committee and the François-Xavier Bagnoud Center for Health and Human Rights. The study is published in the Journal of the American Academy of Child and Adolescent Psychiatry and online at www.jaacap.com. This Release References: 1. Child Soldiers Global Report. http://www.childsoldiersglobalreport.org. Accessed May 12, 2010. 2. Betancourt TS, Brennan RT, Rubin-Smith J, Fitzmaurice GM, Gilman SE. Sierra Leone's Former Child Soldiers: A Longitudinal Study of Risk, Protective Factors, and Mental Health. Journal of the American Academy of Child and Adolescent Psychiatry. 2010;49:606-615. To reach the author you may contact: Dr. Theresa Stichick Betancourt via assistant Sarah Meyers-Ohki at 617 432 1079 or by emai: [email protected] For further information, please contact Rebecca Jensen, Managing Editor, JAACAP, [email protected] or 202.966.7300 x 112. About the Journal of the American Academy of Child and Adolescent Psychiatry The Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) is the official publication of the American Academy of Child and Adolescent Psychiatry. JAACAP is the leading journal focusing exclusively on today's psychiatric research and treatment of the child and adolescent. Published twelve times per year, each issue is committed to its mission of advancing the science of pediatric mental health and promoting the care of youth and their families. The Journal's purpose is to advance research, clinical practice, and theory in child and adolescent psychiatry. It is interested in manuscripts from diverse viewpoints, including genetic, epidemiological, neurobiological, cognitive, behavioral, psychodynamic, social, cultural, and economic. Studies of diagnostic reliability and validity, psychotherapeutic and psychopharmacological treatment efficacy, and mental health services effectiveness are encouraged. The Journal also seeks to promote the well-being of children and families by publishing scholarly papers on such subjects as health policy, legislation, advocacy, culture and society, and service provision as they pertain to the mental health of children and families. About Elsevier Elsevier is a world-leading publisher of scientific, technical and medical information products and services. The company works in partnership with the global science and health communities to publish more than 2,000 journals, including the Lancet (www.thelancet.com) and Cell (www.cell.com), and close to 20,000 book titles, including major reference works from Mosby and Saunders. Elsevier's online solutions include ScienceDirect (www.sciencedirect.com), Scopus (www.scopus.com), Reaxys (www.reaxys.com), MD Consult (www.mdconsult.com) and Nursing Consult (www.nursingconsult.com), which enhance the productivity of science and health professionals, and the SciVal suite (www.scival.com) and MEDai's Pinpoint Review (www.medai.com), which help research and health care institutions deliver better outcomes more cost-effectively. A global business headquartered in Amsterdam, Elsevier (www.elsevier.com) employs 7,000 people worldwide. The company is part of Reed Elsevier Group PLC (www.reedelsevier.com), a world-leading publisher and information provider. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).

Jun 1, 2010

Health

Only 5 percent of cancer research funds are spent on metastases, yet it kills 90 percent of all cancer patients

On average, about five percent of total cancer research funding is spent on investigating metastases (the spread of cancer cells around the body) in Europe, yet metastatic disease is the direct or indirect cause of 90 percent of all cancer deaths, according to an editorial in the European Journal of Cancer (EJC). [1] The authors of the editorial, which introduces a special EJC issue on metastasis ("Stopping cancer in its tracks: metastasis as a therapeutic target"), highlight this discrepancy in funding and they believe that, although it is difficult to obtain accurate figures, the situation is probably similar in other countries such as the USA and Japan. It has been known for some time that metastasis is the key problem in cancer and the main reason why people die from the disease. Until recently, the reasons why some people developed metastases and other did not had been unclear, but, as this special issue of the EJC shows, at last there are models and scientific hypotheses that have begun to unravel this process and the EJC reviews the state of the art in this respect. However, research into metastasis has not necessarily attracted the recognition it deserves from funding organisations. Professor Jonathan Sleeman, one of the two guest editors of the EJC special issue and head of microvascular pathobiology research at the University of Heidelberg (Germany), said: "Metastasis is a process in cancer that is very poorly understood; it kills patients and therefore we believe that it should be funded better. Yet at the European level and, indeed, worldwide, comparatively little emphasis is placed on tackling metastases and in providing appropriate levels of funding for research." He continued: "Given the clinical importance of metastasis for cancer patients, the limited treatment options for metastatic disease and the open question of how metastasis works, we need to know how much research funding is being directed at the problem and what proportion of funding for cancer research ends up focused on metastases? I have found it hard to obtain reliable figures, but although there is considerable variation between European countries, I estimate that the average spent on metastasis research is around 5% of total cancer research funding. Given that metastasis is of central importance to the prognosis and outcome of cancer patients, we could argue that in many countries more funding should be directed toward metastasis research." Metastasis is the process by which cancer cells split off from the original, primary tumour and travel to other parts of the body via the blood or lymph systems. This leads to the growth of secondary tumours in places such as the bones, brain, lungs and liver, and it is usually these that end up killing the patient. "Metastatic disease, therefore, represents a major public health problem, affecting cancer patients and their families, as well as health care systems and the broader economy. Despite this, progress in developing treatments for metastatic disease remains slow," write Prof Sleeman and the second guest editor, Professor Patricia Steeg (chief of the Women's Cancers Section, Laboratory of Molecular Pharmacology at the National Cancer Institute, Bethesda, USA) in their editorial. In addition to adequate funding, they call for: effective translational research for metastatic disease, which will take discoveries made in the laboratory quickly into new and better treatments for cancer patients; clinical trials to be designed so that they include information on metastases; clinicians and scientists to work more closely together to design clinical trials that assess the development of new metastases. "In summary, combating metastasis formation and growth is the key to successfully treating cancer," they conclude. "Traditional growth control approaches are inadequate and can even be detrimental in the long term: new therapies built upon a solid understanding of the process of metastatic disease are urgently required. In turn, this demands an increased pre-clinical knowledge base that capitalises on major conceptual advances made in recent years, as well as a rational approach to the design of clinical trials with the inclusion of metastasis as an end-point. Together these observations speak for the necessity of increasingly close interactions between basic and clinical scientists, as well as the enhanced levels of research funding required to alleviate this major clinical problem." The EJC special issue on metastasis consists of a number of articles looking at the state of current knowledge about the disease and outlining promising areas of research. Prof Steeg said: "We hope that this special issue will highlight the fact that metastasis should be an important consideration during drug development. If more attention was paid to it, we could really improve treatments for cancer patients." The special issue will be available on the Elsevier stand at the American Society of Clinical Oncology (ASCO) meeting in Chicago (USA) from June 4-8. Notes: [1] "Cancer metastasis as a therapeutic target" by Jonathan Sleeman and Patricia S. Steeg. European Journal of Cancer. Volume 46, issue 7, pages 1177-1180 (May 2010). The European Journal of Cancer is the official journal of ECCO -- the European CanCer Organisation. ECCO -- the European CanCer Organisation -- exists to uphold the right of all European cancer patients to the best possible treatment and care and to promote interaction between all organisations involved in cancer research, education, treatment and care at the European level. For more information, visit: www.ecco-eu.org

Jun 1, 2010

Health

TU Delft and MI Labs merge PET and SPECT biomedical imaging techniques and increase resolution

TU Delft and Molecular Imaging Labs (MI Labs) have succeeded in combining two forms of medical imaging techniques into one piece of equipment. These techniques are particularly useful for cancer research. The two techniques are known as microPET and microSPECT. SPECT and PET can be performed simultaneously and they give a higher resolution than traditional microSPECT and microPET. The new device is known as the VECTor (Versatile Emission Computed Tomography) and is designed for use in fundamental research into the functioning of cells and organs. It can show functional details smaller than half a millimetre. Cancer research Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are used in cancer research and diagnosis, among other things. PET and SPECT are also commonly used to carry out fundamental research into living cells and disease mechanisms or to develop better methods of diagnosis and treatment. The equipment that has now been developed at TU Delft and MI Labs is designed for fundamental research using experimental animal models. The combined PET/SPECT apparatus offers extremely high resolution, reduces use of laboratory animals and also offers financial savings when carrying out research in this area. Previously, both types of equipment would have had to be bought separately and less information could be gained from each individual animal. Unprecedented precision Prof. Freek Beekman, professor at TU Delft and CEO/CSO of MI Labs, previously was in charge of developing the U-SPECT, one of the two elements in the new combined apparatus. This U-SPECT (Ultra-high resolution Single Photon Emission Computed Tomographer) is much more precise than the normal SPECT apparatus or other scanning techniques. 'These scanners allow us to see how cells and organs function in unprecedented detail. There are already more than ten U-SPECTs around the globe, which can test new tracers and pharmaceuticals for cancer, cardiac problems and brain diseases,' says Beekman. Early detection The U-SPECT, and later the combined U-SPECT/PET scanner, is currently being used for research using mice. 'The challenge is now to build a U-SPECT that can be used on people, so that tumours can be detected and classified early, for example, and the right treatment can be started immediately,' says Beekman. Medical Delta The further development of U-SPECT is part of the worldwide quest for more efficient medical imaging technology, radiotherapy and tumour seekers. These efforts are slowly but surely leading to ever better cancer treatments, according to Beekman. We still have much to gain by improving technology for detecting and treating cancer. Beekman emphasises that it is important for hospitals and technicians to work together very closely. TU Delft and MILabs are taking action in this area by participating in Medical Delta. They are cooperating with Erasmus University, the University of Leiden and their two affiliated academic hospitals.

Jun 1, 2010

Health

ACR task force makes recommendations for improving relationships between radiologists and hospitals

The American College of Radiology's (ACR) Task Force on Relationships between Radiology Groups and Hospitals and Other Healthcare Organizations has proposed several steps that can help improve relationships between radiologists and the health care systems that they service, according to an article in the June issue of the Journal of the American College of Radiology (www.jacr.org). "The vast majority of U.S. radiologists are affiliated with hospital-based group practices, making professional relationships between radiologists and hospitals one of the most crucial factors in building and maintaining successful and secure practices," said Cynthia S. Sherry, MD, FACR, lead author of the article. "Yet lately tensions between hospitals and radiologists have been increasing," she said. The ACR has assembled a task force on relationships between radiology groups and hospitals and other health care organizations. The task force's goal was not merely to identify problems but to propose positive steps that would benefit radiologists, hospitals, and the patients and communities they serve. "Radiologists must re-dedicate themselves to the concept of service and be more visible to patients, referring physicians, and to the hospital administration. It is imperative for the survival of the specialty for radiologists to provide a "value added" to the clinical evaluations and therapies of patients. This can entail expanded hours of onsite coverage, a greater number of available radiologists, more sub-specialization, and/or greater opportunities for consultations with referring physicians and their patients," she said. "Hospitals should place a high priority on nurturing a functional relationship with their radiology group. A successful relationship will go a long way toward laying a sound bedrock for a radiology service that is optimal for patients, referring physicians, and the administration. Furthermore, hospitals should recognize the core strategic value of a strong foundational radiology service and the critical importance of on-site involvement by radiologists," said Sherry. The June issue of JACR is an important resource for radiology and nuclear medicine professionals as well as students seeking clinical and educational improvement. For more information about JACR, please visit www.jacr.org. To receive an electronic copy of an article appearing in JACR or to set up an interview with a JACR author or another ACR member, please contact Heather Curry at 703-390-9822 or [email protected].

May 31, 2010

Health

Educational researcher devotes May issue to 'Report of the National Early Literacy Panel'

WASHINGTON, D.C., May 31, 2010 -- The May 2010 issue of Educational Researcher (ER) provides a significant scholarly review of Developing Early Literacy: Report of the National Early Literacy Panel (NELP). Educational Researcher is one of six journals published by the American Educational Research Association. In the special issue, NELP Panel members Timothy Shanahan and Christopher J. Lonigan provide a summary of the report followed by nine peer-reviewed commentaries written by literacy scholars who examine the report and offer suggestions for where it illuminates issues and where it is lacking or ambiguous. The commentaries are followed by two responses, written by Shanahan, Lonigan, and Christopher Schatschneider. The National Early Literacy Panel (NELP) Report, issued in 2009, presents the work of the nine-member panel, convened in 2002 by the National Institute for Literacy, in consultation with the National Institute of Child Health and Human Development, U.S. Department of Education, Head Start Bureau, and U.S. Department of Health and Human Services. The report provides the findings of meta-analyses of approximately 300 studies showing which early literacy measures correlate with later literacy achievement. It also provides a series of meta-analyses on ways of teaching early literacy (preschool and kindergarten) that have been published in refereed journals. These analyses examine the effects of code-based instruction, shared book reading, home/parent interventions, preschool/kindergarten interventions, and early language teaching The May ER takes up the topic of early literacy where Developing Early Literacy leaves off, by creating a forum for additional dialogue on future research that needs to be conducted, including translational research and research that will build a sufficient knowledge base concerning early literacy skill development. "The nine [commentary] contributors to this special issue have a long-standing commitment to the early literacy field; they also have broad-based research expertise, an understanding of early literacy practice, and a grasp of the ways in which policy reports, such as the NELP report, if left unexamined, can influence research and pedagogy with unintended consequences," writes Anne McGill-Franzen, the issue's guest editor, in her introduction. "The views of these authors as well as those of the panel are widely respected, and their insight is critical, particularly now as early literacy policy is taking shape on a national level." Early literacy -- the central focus of NELP -- confers a transformative power on individuals, and there now is "a sense of urgency about the need for policy makers, practitioners, and researchers to understand the limitations as well as the strengths of the NELP report," adds McGill-Franzen, Professor of Teacher Education and Director of the Reading Center at the University of Tennessee, Knoxville, College of Education. Commentary authors also provide perspectives that look backward and forward, noted McGill-Franzen. As an example, she cited the lead commentary by P. David Pearson and Elfrieda H. Hiebert, which locates the NELP report "within the universe of scientific reports on reading research, spanning more than five decades' worth of policy contexts." In a reflective article, Susan B. Neuman, formerly Assistant Secretary for Elementary and Secondary Education in the George W. Bush administration, writes, "We need to expose children to language-rich and content-rich settings that can help them acquire the broad array of knowledge, skills, and dispositions that build a foundation for literacy and content learning." Neuman, who conducts research on early childhood policy and early reading instruction in urban settings, is now Professor of Educational Studies at the University of Michigan, School of Education. She argues that effective interventions must mediate a knowledge and technology gap between economically advantaged children and those who are poor. Data reported by NELP underrepresented the importance of language, a slowly acquired and highly complex ability, David K. Dickinson and his colleagues contend. They expressed concern that schools will target the easier to teach code skills, such as letter knowledge and the ability to link sounds to symbols, rather than language and background knowledge, which are harder to teach and may require longer interventions. Commenting on prekindergarten and kindergarten classroom instructional practice, William H. Teale and his colleagues argue that the NELP report is "both insufficiently clear and overly narrow with respect to what preschool teachers should be focusing on instructionally in early literacy." One of the many aspects of early literacy addressed in the ER commentaries focused on dual-language learners (DLLs). Kris D. Gutiérrez and her colleagues point out that dual-language learners are one of the fastest growing populations in the United States, and yet gaps in knowledge exist. They call for "a more expansive research agenda for young DLLs," noting that the field would benefit from "longitudinal studies that examine how children exposed to two languages from an early age develop in relation to their specific individual differences and sociocultural contexts, including different types of educational interventions." The intent of the ER special issue is to provide an introduction to the NELP report and commentaries that foster continued conversation and inquiry around critical issues in the field of early literacy research and practice. Educational Researcher, May 2010 Special Issue: The National Early Literacy Panel Report: Summary, Commentary, and Reflections on Policies and Practices to Improve Children's Early Literacy Guest Editor's Introduction Anne McGill-Franzen, University of Tennessee, Knoxville The National Early Literacy Panel: A Summary of the Process and the Report Timothy Shanahan, Chair of NELP and University of Illinois-Chicago and the Center for Literacy, and Christopher J. Lonigan, Florida State University and the Florida Center for Reading Research National Reports in Literacy: Building a Scientific Base for Practice and Policy P. David Pearson and Elfrieda H. Hiebert, University of California, Berkeley Recognizing Different Kinds of "Head Starts" Marjorie Faulstich Orellana, University of California, Los Angeles, and Jacqueline D'warte, University of California, Irvine Lessons From My Mother: Reflections on the National Early Literacy Panel Report Susan B. Neuman, University of Michigan Speaking Out for Language: Why Language Is Central to Reading Development David K. Dickinson, Vanderbilt University, Roberta M. Golinkoff, University of Delaware, and Kathy Hirsh-Pasek, Temple University Where Is NELP Leading Preschool Literacy Instruction? Potential Positives and Pitfalls William H. Teale, University of Illinois-Chicago, Jessica L. Hoffman, Miami University, and Kathleen A. Paciga, University of Illinois-Chicago Confounded Statistical Analyses Hinder Interpretation of the NELP Report Scott G. Paris and Serena Wenshu Luo, National Institute of Education The NELP Report on Shared Story Reading Interventions (Chapter 4): Extending the Story Judith A. Schickedanz, Boston University, and Lea M. McGee, The Ohio State University Recasting the Role of Family Involvement in Early Literacy Development: A Response to the NELP Report Alanna Rochelle Dail and Rebecca L. Payne, University of Alabama Advancing Early Literacy Learning for All Children: Implications of the NELP Report for Dual-Language Learners Kris D. Gutiérrez, University of Colorado, Marlene Zepeda, California State University, Los Angeles, and Dina C. Castro, University of North Carolina at Chapel Hill Developing Early Literacy Skills:Things We Know We Know and Things We Know We Don't Know Christopher J. Lonigan, Florida State University and the Florida Center for Reading Research, and Timothy Shanahan, University of Illinois-Chicago and the Center for Literacy Misunderstood Statistical Assumptions Undermine Criticism of the National Early Literacy Panel's Report Christopher Schatschneider and Christopher J. Lonigan, Florida State University and the Florida Center for Reading Research Editor's Note: The full text of this special issue of Educational Researcher, "The National Early Literacy Panel Report: Summary, Commentary, and Reflections on Policies and Practices to Improve Children's Early Literacy," is posted on the AERA Web site: www.aera.net (http://www.aera.net/publications/Default.aspx?menu_id=38&id=9962) The full text of the NELP Report, Developing Early Literacy: Report of the National Early Literacy Panel, A Scientific Synthesis of Early Literacy Development and Implications for Intervention, is posted here: http://www.nifl.gov/earlychildhood/NELP/NELPreport.html To reach AERA Communications, call (202)238-3200; Helaine Patterson ([email protected]) or Lucy Cunningham ([email protected]). The American Educational Research Association (AERA) is the national interdisciplinary research association for approximately 25,000 scholars who undertake research in education. Founded in 1916, AERA aims to advance knowledge about education, to encourage scholarly inquiry related to education, and to promote the use of research to improve education and serve the public good.

May 31, 2010

Health

Regional differences in C-section rate not a result of maternal request: UBC study

Fewer than two per cent of cesarean births in British Columbia were a result of maternal request, but the number of cesarean and assisted vaginal deliveries varied widely across health regions in B.C., according to a new study by University of British Columbia researchers. "There is a misconception that the overall increase of cesarean births is the result of maternal request," says lead author Gillian Hanley, a PhD student in the UBC School of Population and Public Health. "Our analysis of B.C. data shows that this is not the case." Published in the June issue of the journal Obstetrics & Gynecology, the UBC study examined all deliveries in B.C. between 2004 and 2007 and found an average of 21.2 per 100 deliveries were first-time C-sections and 14.2 per 100 deliveries were assisted vaginal deliveries involving the use of forceps and/or vacuum devices. Dystocia -- or abnormal or difficult childbirth -- was the most common reason for cesarean deliveries (30 per cent), followed by non-reassuring fetal heart rate (19.1 per cent). Canada's cesarean delivery rate has increased dramatically over the past two decades, reaching an all time high of 26.3 per cent of in-hospital deliveries in 2005-2006. Until recently, B.C. had the highest cesarean rate in the country, according to the Canadian Institute for Health Information. The study also found significant regional variations in cesarean and assisted vaginal delivery rates across B.C.'s 16 Health Services Delivery Areas that could not be explained by accounting for medical indications for these procedures. Cesarean delivery rates ranged from 27.5 per cent in the South Vancouver Island area to 16.1 per cent in Kootenay Boundary. Assisted vaginal delivery rates ranged from 18.6 per cent in Vancouver to 8.6 per cent in East Kootenay. "In other words, some regions are either performing too many or too few cesareans after taking into consideration the characteristics and conditions of the mothers," says Hanley, also a researcher at the UBC Centre for Health Services and Policy Research. "Our study doesn't attempt to determine the ideal rate of cesarean or assisted vaginal delivery," says Hanley. "But since regional variation is a fundamental principal in assessing the quality of health care, we need to further investigate the reason behind these large differences within the province's system." The researchers suggest potential reasons may include the differences in practitioners' responses to similar medical situations, such as dystocia, including how they interpret and respond to the condition, and how they factor the resources available to them into their decisions. "For example, smaller institutions may lack the resources required to respond to medical emergencies in the same manner as a tertiary care facility," says Hanley. "It is therefore more likely for practitioners there to recommend a cesarean delivery with a lower medical threshold. "These hypotheses should be further investigated and may include non-medical factors such as socio-economic status," says Hanley. "But the findings point to a need for revising current national guidelines regarding the management of dystocia." Co-authors of the study include Assoc. Prof. Patricia Janssen at the School of Population and Public Health and Devon Greyson, data specialist at the Centre for Health Services and Policy Research.

May 31, 2010

Health

Lack of private insurance contribute to higher deaths among black heart transplant patients

Transplant surgeons at Johns Hopkins who have reviewed the medical records of more than 20,000 heart transplant patients say that it is not simply racial differences, but rather flaws in the health care system, along with type of insurance and education levels, in addition to biological factors, that are likely the causes of disproportionately worse outcomes after heart transplantation in African Americans. In a report on the review to be published in the Annals of Thoracic Surgery online June 1, the Johns Hopkins team showed that race matching donor hearts did nothing to extend the life in organ recipients. Race matching is the practice of transplanting donor hearts into patients of the same ethnic group. White donors would be matched to white recipients, and the same would apply to blacks, Hispanics or Asians. "It does not matter whether a white, black, Hispanic or Asian donor heart is transplanted into a patient of any other particular race," says senior study investigator and Johns Hopkins transplant surgeon Ashish Shah, M.D. "Other factors must be the reason for any differences in how well people do after transplantation, in particular, why blacks have poorer outcomes." In what is believed to be the largest and most detailed review of medical records ever conducted on the subject, the Johns Hopkins team combed 20,185 North American transplant patients' records. All received a donor heart between 1997 and 2007. Researchers found that 61 percent of heart recipients were race matched (12,381). Among blacks, the death rate after five years was the same, at 35 percent, whether donors and recipients were race matched or not. The same was true among whites, at 26 percent, and among Hispanics, at 28 percent. (Although trends appeared to be the same for Asians, the number of transplants in Asians was not statistically large enough to provide valid percentages.) Death or survival rates were consistent for all timeframes, within a month, three months, six months or a year after transplantation. Study investigators found that race matching did little or nothing to close the significant gap in blacks' survival rates. Whether or not African Americans received a heart from a black donor, they faced a 46 percent higher chance of dying within 10 years after heart transplantation. Specifically, 45.8 percent of blacks were alive and well after 10 years, a rate 11.4 percent lower than for whites and 10.8 percent lower than for Hispanics. Researchers say previous reports from nearly a dozen other academic medical centers offered conflicting accounts about any potential benefits from race matching. They say the latest study findings help set the clinical record straight by pooling data from more than 140 hospitals licensed to perform heart transplants instead of relying on data within individual hospitals. Shah says the data "really prompts us to re-evaluate everything that we do for our more vulnerable patients and to tailor our efforts to the specific needs of each patient, especially African Americans, if we hope to fix racial disparities in surviving heart transplantation. "This problem is not just about biology or race, it is also about the health system that supports our patients," says Shah, an associate professor at the Johns Hopkins University School of Medicine and its Heart and Vascular Institute. He also notes that transplant patients can now put their minds at ease that having a racially matched donor heart will not help or hurt them. Lifting survival rates among blacks, who represent 15 percent of all heart transplants, will, Shah says, require further study of which life-extending factors may work, such as antirejection drug dosages, more stringent follow-up to ensure patient compliance with drug regimens and scheduled appointments, and education about early signs of infection and possible organ rejection, including fever, shortness of breath, fatigue, and swelling in the arms and legs. Among the researchers' other key findings were that such problems related to organ rejection within the first year, regardless of race, were tied to insurance and education. Patients with public insurance, specifically Medicaid, had a 30 percent higher risk of needing some kind of antirejection treatment and a 39 percent higher risk of dying than transplant recipients with private insurance. Transplant recipients on Medicare did not fare well either, with a 12 percent higher risk of dying than those with private insurance. Having a college education lowered the overall group's likelihood of having a rejection-related problem with their transplant by 12 percent. In the study population, 20.5 percent of black transplant recipients had Medicaid insurance compared to 8.8 percent of other races, and fewer had private insurance (49.9 percent) compared to others (63.6 percent). The African-American group as a whole had a lower percentage of college graduates than other races (at 40.6 percent and 50.3 percent). Black recipients also had a higher degree of tissue antigen mismatches with their transplanted hearts compared to other groups (at 65.4 percent and 55.6 percent.) The better the match, Shah says, the better the chances that immunosuppressive drugs will work over the long term to prevent organ rejection. Hypertension and gender mismatches, factors known to up the chances of dying, were also more widespread among African Americans. Lead study investigator Jeremiah (Geoff) Allen, M.D., says a combination of these circumstances in African Americans likely contribute to their poorer outcomes. Allen, a postdoctoral research fellow in cardiac surgery at Johns Hopkins, says the team's next steps are to identify which combination of factors stands out among those blacks who survive long term post-transplant and those who do not. Some 45 percent of African Americans with donated hearts, he notes, survived longer than 10 years. An early identification system for those at higher risk of rejection and death, and data on any differences in treatment protocols could help narrow the survival gap for blacks, he says. "This research is key to correcting the survival disparity in African Americans in surviving heart transplantation, and helps us learn how to take better care of some of our most high-risk transplant recipients," says Allen. The data used in the study came from the United Network for Organ Sharing (UNOS), a national network that allocates donated organs across the United States. Funding for the study was supplied in part by the The Johns Hopkins Hospital, with additional support from the U.S. Department of Health and Human Services and its Health Resources and Service Administration. In addition to Shah and Allen, other Johns Hopkins researchers involved in this study were Eric Weiss, M.D., M.P.H.; George Arnaoutakis, M.D.; Stuart Russell, M.D.; William A. Baumgartner, M.D.; and John Conte, M.D. For additional information, go to: http://www.hopkinsmedicine.org/Transplant/Programs/heart/ http://www.ishlt.org/

May 30, 2010