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Tokyo Medical and Dental University

Researchers investigated the function of PQBP3, a protein that was previously linked to certain neurodegenerative diseases, and unveiled its role in maintaining the integrity of the nuclear membrane. In senescent (aged) cells, PQBP3 concentration is decreased thereby promoting Lamin B1 degradation, and PQBP3 leaks from its typical place in the nucleolus to the cytosol, which in turn causes the nuclear membrane to get destabilized.

Protein Discovery Illuminates Link Between Aging and Brain Diseases

Categories Brain & Behavior

Loss of A20 function in hepatic stellate cells upregulated the DCLK1-JNK phosphorylation axis. DCLK1 enhances chemokine expression, leading to progression of chronic hepatitis.

New Protein Target Could Lead to Better Treatments for Chronic Hepatitis

Categories Health

Japanese researchers studied the effects of locally administered ASOs on mouse models of Parkinson's disease. Their research indicates that ASOs can help prevent the formation and spread of harmful alpha-synuclein aggregates in different brain regions, suggesting ASOs as a potential therapeutic strategy for preventing and controlling the progression of neurodegenerative diseases.

New Treatment Approach Shows Promise in Slowing Parkinson’s Disease Progression

Categories Brain & Behavior, Health

Brain proteins

Enemy turned ally: Ancient viral genes protect the brain against new infections

Categories Brain & Behavior, Health

NCAM1 is induced only in green cells (HeLa cells). Serum from patients with anti-NCAM1 autoantibody react only to green cells (framed in red).

New evidence for an autoimmune cause of schizophrenia

Categories Brain & Behavior, Health

Anti-cancer ‘dream cream’ shrinks oral tumors

Categories Health

Melatonin: A supplement that actually boosts memory

Categories Brain & Behavior

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