GDF11: A hormonal candidate for rejuvenation
I did a series last fall [1, 2, 3] on the thesis that aging is a program of self-destruction, executed under the control of hormonal signals in the blood.
May 5, 2014
Aging & evolutionary biology
Josh Mitteldorf is best known for promoting the theory that aging is not “wearing out” but rather an evolved program that limits lifespan. The surprising fact that our bodies are genetically programmed to age and to die offers an enormous opportunity for medical intervention. He began blogging about aging on this site in 2012. His guidance for a long life is at AgingAdvice.org. His two books on aging are available at Amazon and elsewhere.
Mitteldorf’s PhD is in astrophysics. Since about 2020, he has taken up a new challenge as curator and critic of science on the fringe, writing about promising science that the science establishment has unjustly neglected.
In other areas of life, Mitteldorf’s two daughters were among the first girls to be adopted from China in the 1980s. He has taught a weekly yoga class for fifty years. He is an avid amateur musician, playing piano in chamber groups, French horn in community orchestras. Follow his other writing at mitteldorf.substack.com, and listen to his poetry on YouTube.
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I did a series last fall [1, 2, 3] on the thesis that aging is a program of self-destruction, executed under the control of hormonal signals in the blood.
May 5, 2014
Curcumin is extracted from the turmeric root, a common Indian spice with a long tradition of healing applications.
May 1, 2014
If you have followed this blog for any length of time, you have probably figured out that I came to the science of aging through evolutionary biology, and that I believe evolutionary thinking is a key to understanding what aging is and how it can be addressed.
Apr 23, 2014
Friends often look at me quizzically when I tell them this. One says, “But I can feel myself wearing down.” And another: “Nothing works the way it used to.
Apr 7, 2014
The two greatest fitness inventions of all time (in my humble opinion) are the bicycle and the stairwell.
Apr 3, 2014
Last year, the Federal CDC backed off from 50 years of advising everyone (and especially heart patients) to limit their salt intake.
Apr 3, 2014
In a paper published late last year, a cautious and expert biochemist reports that none of the most popular “life extension supplement” mixes actually extend life span in mice.
Mar 25, 2014
One reason that there is still so much uncertainty in anti-aging medicine is that we can’t do experiments on humans the way we do on mice.
Mar 21, 2014
Recent re-analysis suggests that Alzheimer's Disease ought to be ranked with cancer and heart disease as one of the most important mortality risks for older Americans.
Mar 12, 2014
Carnosine is a good supplement, with many studies offering indirect evidence for effects that ought to be beneficial.
Mar 5, 2014
One-minute workouts - a list of exercises 0. Stairs are a terrific resource - available almost everywhere people live and work.
Feb 25, 2014
A lot of people still try to understand aging as a kind of accumulated damage, or wear-and-tear.
Feb 17, 2014