Human Theome Project

This is one of the most serious pieces ever posted on Genotopia. As the shooting at the French humor magazine Charlie Hebdo shows, satire can be dangerous business. It is also one of the most important forms of speech—both provocative and healing. We are reposting this feature, originally posted in 2011 and lightly edited, to lock arms with the staff and writers at Charlie Hebdo and with satirists everywhere. We hope it offends someone and are glad that our home address is not public.

 

Joe and Mary Juke are models of piety. They attend services twice a week, are active in faith-based charity organizations, and their house brims tastefully with Christian iconography and literature. They describe themselves as “fundamentalists,” although Joe is quick to emphasize, “We’re moderate fundamentalists—we don’t bomb clinics or anything.” They are planning to have a family, and they are making sure to create a pious environment for their children. They know that the setting in which a child is raised helps determine the kind of adult he or she becomes.

But for the Jukes, books, icons, and saying “Grace” are not enough. In what is being cited as a milestone in personal genomics, Joe and Mary have taken steps to ensure their baby is religious—by selecting its genes.

 

Using preimplantation genetic diagnosis (PGD), a combination of genetic screening and in vitro fertilization (IVF), Joe and Mary are loading the genetic dice for their progeny, selecting embryos that carry the traits they want in little Joe Jr. (or mini-Mary). Modern techniques allow them to select for a wide range of qualities, from avoiding hereditary diseases, to selecting eye, hair, and skin color, to shaping aspects of personality. For example, choosing a combination of half a dozen genes allows them to add a cumulative 40 points to their unborn child’s IQ. Many of these tests have been available for years, although they have only recently begun to be available to consumers. But the most striking decision in their family-planning process was to expressly select for embryos that will grow up to be religious, because they carry the allele known colloquially as the “god gene.”

“It kind of gives a whole new meaning to the phrase, “Chosen One,” Mary says.

Sequencing the human theome

The gene, which was identified statistically in twins in a study published in 2005, was recently cloned and sequenced, as reported in the online journal Nature Theology. Dubbed yhwh1, the gene correlates strongly with feelings of religious fervor. Studies show that the gene encodes a protein that is expressed in a part of the brain called Chardin’s area 86, long associated with religious activity and, strangely, anterograde amnesia. One famous patient was Guineas Phage, a virologist who suffered an injury with a pipetteman that resulted in a plastic tube being driven precisely into area 86; he spent the last two decades of his life on a constant pilgrimage along US Route 66 between Kingman and Barstow, accompanied by his wife, Winona, whom he continually left behind at gas stations.

Particular expression of religiosity in a given individual varies according to environment; what is inherited is the capacity for intense religious experience and evangelism. First described in the Amish in a classic study of the 1960s, the trait was described as an autosomal recessive with high penetrance, and was linked to a rare inherited form of dwarfism. Recent analyses have also found the trait occurring at high frequency among charismatic ministers, shamans, and suicide bombers.

The yhwh1 allele is one of the latest findings in the burgeoning field of “theomics,” which aims to identify all genes associated with the practice of preaching, as well as general feelings of spirituality. The Human Theome Project overran its projected completion date of December 21, 2012—the date, according to ABC News, the world as we know it might have come to an end. All things considered, then, researchers are content with their progress.

Here are some of the most exciting new findings of the HTP:

▪   Scientists estimate that at least 400 genes are involved with religious feelings or activity. Thus far, more than 100,000 variants have been described. Easing the task of studying these genes is the fact that they cluster into “ecclesiotypes” — groups of religion genes that tend to segregate together. A research team at Mystic University in Connecticut is coordinating an effort, called the “EccMap project,” to characterize them.

▪   The EccMap project consists of 400 trios  (god, parent, and child) representing each of the five dominant world religions—christianism, judaishness, islamian, confusianity, and pastafar-I. Researchers say these explain 80% of genetic variation for religious belief.

▪   Polytheism is more common than had been thought. Ninety-five percent of all trios in the EccMap project have genes for at least two religions. Since phenotype is almost always monotheist, this suggests that the environment may play some role in fine-tuning religious beliefs.

▪   A related project seeks to uncover the epigenetics of evangelism, which is thought to be caused by methylation of regions of the X chromosome, a reversible process that can profoundly affect gene expression. Researchers hope this may provide therapeutic targets for drugs or gene therapy to “de-program” those who become convinced, against thousands of years of recorded history, that theirs is the only path up the spiritual mountain.

▪   A newly discovered kinase, called Bub666, is strongly correlated with atheism. It seems to be responsible for the breakdown of yhwh1, suggesting that biochemists are approaching a mechanistic explanation of religious experience.

▪   Rocker Ozzy Osborne has had his genome sequenced. Preliminary results show 85% homology with a Presbyterian minister from Des Moines.

“It’s tremendously exciting research,” said Mary Magdalene-Gohdtsdottir, a senior researcher in the University of Utah’s Department of Omics. “Just think of it: the genes for God! Isn’t that cool?” Indeed, the federal government thinks so. NIH Director Francois Colon, a molecular biologist and born-again Christian, has recently created a National Institute of the Molecular Biology of Yahweh (NIMBY), with an annual research budget of $400/year, as part of the government’s effort to support faith-based initiatives in biomedicine.

 

But is it science?

Some critics have called the Jukes’ actions a step toward eugenics, described in the 1920s as the “self-direction of human evolution.” They see religiosity as a gift, not something that can be ordered from a catalog. “This is an outrage,” said the Reverend Reginald S. Inkblot, of Southboro Baptist Church in Onan, Kansas. “Religion can’t be in your genes. Science can’t explain it. It’s just a part of who…you…um, are. It’s just in your…uh, yea…” He brightened and added, “If God had wanted us to be religious, he would have….oh, wait. Damn!—I mean, darn!”

Others are appalled that religion would receive scientific consideration from scientific foundations at all. Dick Dorkins, President of the atheistic Society for the Prevention of Intelligent design, Theology, Or Other Nonsense (SPITOON), calls the entire effort a “travesty.” “If I must check my brain at the church-house door,” he said in a Skype interview, “then you must check your soul at the laboratory door. Come on—be fair.”

Dorkins worries that should the procedure become widespread, it could lead to nonreligious persecution. If those chosen by PGD tend to express genes such as yhwh1, scientists predict, it could lead to changes in gene frequency across the population. Dorkins envisions a dystopian scenario in which an atheistic underclass washes the wineglasses and polishes the pews for their genetic spiritual superiors. “It will be GATTACA crossed with The Ten Commandments,” Dorkins said, an audible quiver in his voice.

Evolution in religious hands

Some theologians have condemned in vitro fertilization because it normally results in the destruction of unused embryos. However, new gene therapy techniques make it possible to link a “suicide gene” to alternative forms of the desired genes in Joe’s sperm samples; thus, only sperm that carry the traits they want survive to fertilize Mary’s eggs. No embryos are destroyed in the process. This makes in vitro fertilization acceptable to many pro-life Christians.

Joe and Mary dismiss critics who say they are taking evolution into their own hands. “That’s just your theory,” says Joe. They view their decision to choose the religiosity of their unborn child as a command from above. “WWJC?,” Mary asks. “Who would Jesus clone?”

Ironically, as Biblical literalists, the Jukes dismiss Darwinian evolution as “unproven.” To them, the earth is 4,000 years old, and all the types of animals in the world today were on Noah’s Ark. They see themselves as spearheading a Crusade of believers into biomedicine.

His eye acquiring that spark of evangelism that is a tell-tale sign of heavy methylation at Xq66, Joe’s voice deepened and he intoned, “The heresy of modern science will only be righted when human evolution is safely in the hands of people who do not believe in it.”