Cancer-Seeking Nanomotors Use Light to Unleash a Triple Chemical Attack on Tumors

Researchers built tiny particles called PFB@CM nanomotors by coating a drug-loaded core with a shell made from cancer cell membranes. The cancer cell coating helps the particles blend in with tumors and avoid being rejected by the body. When exposed to near-infrared light, the particles heat up. That heat does three things at once: it propels the particles into cancer cells, triggers the release of nitric oxide (NO), and frees up iron ions. The iron reacts with hydrogen peroxide already present in the tumor to produce a toxic molecule called hydroxyl radical (·OH). That radical then combines with the nitric oxide to form peroxynitrite (ONOO⁻), which kills cancer cells. The upshot: light turns these particles into self-guided, multi-pronged cancer killers.

A bowl-shaped particle, roughly a quarter of a micrometre across, drifts through the bloodstream. It’s wearing a disguise: a fragment of membrane stripped from a breast cancer cell, studded with the same proteins that cancer cells use to recognise each other. The immune system ignores it. The particle reaches a tumour, docks, and waits. Then … Read more

How Scientists Learned to Read Information Encoded in Darkness Inside Light

Schematic and working principles of the LightELF system.​ LightELF is a neuromorphic high-throughput optical data transmission prototype that uses the topological invariants of optical singularity evolution as the information medium.

Inside a beam of light, there are places where the light simply isn’t. Not dim, not scattered, not absorbed. Absent, a void of zero intensity threading through the beam like a knotted vein of darkness. These are phase singularities: points where the electromagnetic phase becomes undefined, where the wave collapses into nothing. They dart through … Read more

Ancient Herbal Remedy Produces Nanomedicine When You Boil It

concoction boiling over a fire

Boiling water destroys things. That, more or less, is the assumption underlying decades of nanomedicine research, which has largely ignored traditional herbal teas and decoctions as sources of therapeutic nanoparticles. Lipid membranes, the reasoning went, simply don’t survive prolonged exposure to 100 degrees Celsius. They rupture. They disintegrate. And so researchers seeking plant-derived nanoparticles have … Read more

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